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Title: Synthesis and antimicrobial activity of thiazolidinone norfloxacin hybrids
Authors: Kumar, Vikas
Kumar, Ashok
Sharma, Shalabh
Singh, Netra Pal
Keywords: Quinoline;Schiff base;Thiazolidinone;Antibacterial activity;Antifungal activity
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Abstract: A new series of 1-ethyl-6-fluoro-7-piperazinyl-4-oxo-3-(substitutedarylidinylcarboxy-hydrazido)quinolines 3-7 and 1-ethyl-6-fluoro-7-piperazinyl-4-oxo-3-(2¢-substitutedaryl-4¢-oxo-1¢,3¢-thiazolidin-3¢-yl)aminocarboxyquinolines 8-12 have been synthesized in order to determine their antimicrobial activities and feasible structure-activity relationships. The synthesized compounds and reference drugs have been tested in vitro against various strains of bacteria: E. coli ATCC 25922, B. subtilis ATCC 1633 and S. aureus ATCC 25923 and the fungi: C. albicans ATCC 2091, A. niger ATCC 9029 and C. krusei ATCC 6258. Microbiological results showed that the synthesized compounds possessed a broad spectrum of antimicrobial activity against the microorganisms tested. 1-Ethyl-6-fluoro-7-piperazinyl-4-oxo-3-[2¢-(o-methoxyphneyl)-4¢-oxo-1¢,3¢-thiazolidin-3¢-yl)aminocarboxyquinoline 10 has displayed more potent antibacterial activity as compared to standard drug, chloroamphenicol and rest of the compounds of this series. This compound has also exhibited significant antifungal activities, which is not more than that of fluconazole. The structural assignments of newly synthesized compounds are based on IR, 1H NMR, mass spectral studies and elemental analysis.
Page(s): 1496-1503
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(10) [October 2011]

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