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Title: Synthesis, characterization and antibacterial activity of benzimidazole derivatives carrying quinoline moiety
Authors: Gowda, Janardhana
Khader, A M A
Kalluraya, Balakrishna
Hidayathulla, Syed
Keywords: Benzimidazoles;Quinolines;2-(1H-benzimidazol-2-yl)thieno[2,3-]quinoline;Antibacterial activity
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Abstract: A new series 2-(1H-benzimidazol-2-yl)-6-substitutedthieno[2,3-b]quinolines 4 have been synthesized by a one-step process in which 2-(chloromethyl)-1H-benzimidazole 2/2-(mercaptomethyl)-1H-benzimidazoles 6 undergo nucleophilic substitution and cyclisation with 2-mercaptoquinoline-3-carbaldehyde 1/2-chloroquinoline-3-carbaldehyde 5. The compounds have been synthesized by two methods to select a method of higher yield. The newly synthesized compounds have been characterized by IR, CHNS analysis, LC-MS and 1H NMR and also screened for antibacterial activity.
Page(s): 1491-1495
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(10) [October 2011]

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