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Title: Synthesis, characterization and antibacterial activity of benzimidazole derivatives carrying quinoline moiety
Authors: Gowda, Janardhana
Khader, A M A
Kalluraya, Balakrishna
Hidayathulla, Syed
Keywords: Benzimidazoles
Antibacterial activity
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Abstract: A new series 2-(1<i>H</i>-benzimidazol-2-yl)-6-substitutedthieno[2,3-<i>b</i>]quinolines <b style="">4</b> have been synthesized by a one-step process in which 2-(chloromethyl)-1<i>H</i>-benzimidazole <b style="">2</b>/2-(mercaptomethyl)-1<i>H-</i>benzimidazoles <b style="">6</b> undergo nucleophilic substitution and cyclisation with 2-mercaptoquinoline-3-carbaldehyde <b style="">1</b>/2-chloroquinoline-3-carbaldehyde <b style="">5</b>.<b style=""> </b>The compounds have been synthesized by two methods to select a method of higher yield. The newly synthesized compounds have been characterized by IR, CHNS analysis, LC-MS and <sup>1</sup>H NMR and also screened for antibacterial activity.
Description: 1491-1495
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(10) [October 2011]

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