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Title: Synthesis and antibacterial activity of some new spiro[pyrano[2,3-<i style="">f</i>]chromen-2,1'-cycloalkan]-4-ones and 1'-alkylspiro[pyrano[2,3-<i style="">f</i>]chromen-2,4'-piperidin]-4-ones
Authors: Sreenivas, P
Reddy, S Satyanarayana
Rao, Y Jayaprakash
Rao, Ch Prasada
Krupadanam, G L David
Keywords: Regioselective synthesis
[3,3]Sigmatropic shift
Pyrano spirochromanones
Antibacterial activity
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Abstract: Claisen rearrangement of 7-propargyloxyspirochromanones in <i style="">N,N</i>-diethylaniline affords spiro[pyrano[2,3-<i style="">f</i>]chromen-2,1'-cyclo¬≠alkan]-4-ones, while 1'-alkylspiro[pyrano[2,3-<i style="">f</i>]chromen-2,4'-piperidin]-4-ones can be synthesized by Claisen rearrangement of 4-propargyloxyresaectophenones followed by cyclization using <i style="">N</i>-subsituted piperidones in ethanol-pyrrolidine. All the compounds have been tested <i style="">in vitro</i> for their antibacterial activity against Gram-positive bacteria <i style="">Bacillus subtilis</i> and <i style="">Staphylococcus aureus</i> and Gram-negative bacteria <i style="">Escherichia coli</i> and <i style="">Pseudomonas aeruginosa</i>. Some of the compounds show moderate to good antibacterial activity.
Description: 1484-1490
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(10) [October 2011]

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