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IJC-B Vol.50B(10) [October 2011] >


Title: Synthesis and antibacterial activity of some new spiro[pyrano[2,3-f]chromen-2,1'-cycloalkan]-4-ones and 1'-alkylspiro[pyrano[2,3-f]chromen-2,4'-piperidin]-4-ones
Authors: Sreenivas, P
Reddy, S Satyanarayana
Rao, Y Jayaprakash
Rao, Ch Prasada
Krupadanam, G L David
Keywords: Regioselective synthesis
[3,3]Sigmatropic shift
Pyrano spirochromanones
Antibacterial activity
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Abstract: Claisen rearrangement of 7-propargyloxyspirochromanones in N,N-diethylaniline affords spiro[pyrano[2,3-f]chromen-2,1'-cyclo¬≠alkan]-4-ones, while 1'-alkylspiro[pyrano[2,3-f]chromen-2,4'-piperidin]-4-ones can be synthesized by Claisen rearrangement of 4-propargyloxyresaectophenones followed by cyclization using N-subsituted piperidones in ethanol-pyrrolidine. All the compounds have been tested in vitro for their antibacterial activity against Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus and Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa. Some of the compounds show moderate to good antibacterial activity.
Page(s): 1484-1490
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.50B(10) [October 2011]

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