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Title: Effect of oleo-gum-resin of <i>Boswellia serrata </i>(<i style="">Kundur</i>) on renal functions in Albino rats
Authors: Alam, Mahe
Javed, K
Jafri, MA
Keywords: Gentamicin
<i style="">Kundu</i>
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Series/Report no.: <b style="">Int. Cl.<sup>8</sup></b>: A01D 13/38, C07H 15/234, A61K 39/00, C09K 15/00, C09F
Abstract: Oleo-gum-resin of <i>Boswellia serrata</i> Roxb. (Burseraceae) locally called ‘<i style="">Kundur’</i>, is one of the ingredients in certain Unani formulations used in renal diseases. In the present study, the effect of <i style="">Kundur</i> and its methanol soluble (MS), and methanol insoluble (MINS) fractions were investigated on Gentamicin induced nephrotoxicity in Albino rats. The renal effects of <i style="">Kundur</i> and its fractions were studied by monitoring urea and creatinine blood levels. Aminoglycoside antibiotics including Gentamicin are widely used in the treatment of Gram-negative bacterial infections. A major complication of the use of these drugs is nephrotoxicity. In the current study, treatment with <i style="">Kundur</i> its methanol soluble (MS) and methanol insoluble (MINS) fractions significantly prevented the rise in blood urea and serum creatinine levels. Our results suggest that <i style="">Kundur</i> and its (MS) methanol soluble fraction induced renoprotective action against Gentamicin induced nephrotoxicity probably due to the presence of compounds possessing antioxidant potential.
Description: 736-740
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.10(4) [October 2011]

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