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Title: Comparative toxicity study of various dosage forms of <i style="">Sammul far </i>(Arsenic trioxide) in mice
Authors: Shamim, Irshad
Wadud, Abdul
Najeeb, Jahan
Sofi, Ghulamuddin
Ahmad, Ghufran
Keywords: <i style="">Sammul far</i>
<i style="">Kushta</i>
<i style="">Mudabbar</i>
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Series/Report no.: <b style="">Int. Cl.<sup>8</sup>: </b>C01G 28/00, A01K 39/00, A01D 15/00, A01D 15/07
Abstract: <i style="">Sammul far</i> (Arsenic trioxide) is a poison but its use in Unani medicine as a therapeutic agent is common, of course, after subjecting it to various processes of detoxification. Two forms of processed Arsenic, i.e. simply processed by grinding it along with certain other drugs (<i style="">Mudabbar/</i>detoxified form), and by burning it at a very high temperature and getting its oxide (<i style="">Kushta</i>/calcined form) are widely used by Unani physicians. However, these two forms have not been studied scientifically for their toxic potential or pharmacological and therapeutic profile. Therefore, a study was designed to evaluate acute and sub acute toxicity of <i style="">Sammul far</i> processed by different methods in albino mice with an aim to prepare their toxicity/safety profile and find the safest dosage form through their inter comparison. The data obtained from the study were analyzed by using <i style="">Kruskal Wallis</i> with Dunn’s multiple pair comparison test, and ANOVA non- repeated measure. A thermogram was also prepared by recording the heat pattern during the course of preparation of <i style="">Kushta</i> by conventional method (as described in Unani literature) and was standardized for preparation of <i style="">Kushta </i>by a furnace. The study revealed <i style="">Mudabbar </i>form to be more toxic than the calcined form. Further, <i style="">Kushta</i> prepared by furnace was safer than that prepared by classical method.
Description: 721-726
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.10(4) [October 2011]

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