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Indian Journal of Traditional Knowledge (IJTK) >
IJTK Vol.10 [2011] >
IJTK Vol.10(4) [October 2011] >
| Title: | Comparative toxicity study of various dosage forms of Sammul far (Arsenic trioxide) in mice |
| Authors: | Shamim, Irshad
Wadud, Abdul
Najeeb, Jahan
Sofi, Ghulamuddin
Ahmad, Ghufran |
| Keywords: | Sammul far
Kushta
Mudabbar
Thermogram
Toxicity |
| Issue Date: | Oct-2011 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. Cl.8: C01G 28/00, A01K 39/00, A01D 15/00, A01D 15/07 |
| Abstract: | Sammul
far (Arsenic trioxide) is a poison but its use in
Unani medicine as a therapeutic agent is common, of course, after subjecting it
to various processes of detoxification. Two forms of processed Arsenic, i.e.
simply processed by grinding it along with certain other drugs (Mudabbar/detoxified form), and by
burning it at a very high temperature and getting its oxide (Kushta/calcined form) are widely used by
Unani physicians. However, these two forms have not been studied scientifically
for their toxic potential or pharmacological and therapeutic profile.
Therefore, a study was designed to evaluate acute and sub acute toxicity of Sammul far processed by different methods
in albino mice with an aim to prepare their toxicity/safety profile and find
the safest dosage form through their inter comparison. The data obtained from
the study were analyzed by using Kruskal
Wallis with Dunn’s multiple pair comparison test, and ANOVA non- repeated
measure.
A thermogram was also prepared by recording the heat pattern during the course
of preparation of Kushta by
conventional method (as described in Unani literature) and was standardized for
preparation of Kushta by a furnace.
The study revealed Mudabbar form to
be more toxic than the calcined form. Further, Kushta prepared by furnace was safer than that prepared by
classical method. |
| Page(s): | 721-726 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1068 (Online); 0972-5938 (Print) |
| Source: | IJTK Vol.10(4) [October 2011]
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