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Title: Comparative toxicity study of various dosage forms of Sammul far (Arsenic trioxide) in mice
Authors: Shamim, Irshad
Wadud, Abdul
Najeeb, Jahan
Sofi, Ghulamuddin
Ahmad, Ghufran
Keywords: Sammul far;Kushta;Mudabbar;Thermogram;Toxicity
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: C01G 28/00, A01K 39/00, A01D 15/00, A01D 15/07
Abstract: Sammul far (Arsenic trioxide) is a poison but its use in Unani medicine as a therapeutic agent is common, of course, after subjecting it to various processes of detoxification. Two forms of processed Arsenic, i.e. simply processed by grinding it along with certain other drugs (Mudabbar/detoxified form), and by burning it at a very high temperature and getting its oxide (Kushta/calcined form) are widely used by Unani physicians. However, these two forms have not been studied scientifically for their toxic potential or pharmacological and therapeutic profile. Therefore, a study was designed to evaluate acute and sub acute toxicity of Sammul far processed by different methods in albino mice with an aim to prepare their toxicity/safety profile and find the safest dosage form through their inter comparison. The data obtained from the study were analyzed by using Kruskal Wallis with Dunn’s multiple pair comparison test, and ANOVA non- repeated measure. A thermogram was also prepared by recording the heat pattern during the course of preparation of Kushta by conventional method (as described in Unani literature) and was standardized for preparation of Kushta by a furnace. The study revealed Mudabbar form to be more toxic than the calcined form. Further, Kushta prepared by furnace was safer than that prepared by classical method.
Page(s): 721-726
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.10(4) [October 2011]

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