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Title: A clinical study on the management of generalized anxiety disorder with Vaca (Acorus calamus)
Authors: Bhattacharyya, D
Sur, TK
Lyle, N
Jana, U
Debnath, PK
Keywords: Anxiety disorders
Psychological stress
Acorus calamus
Ayurvedic medicine
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
IPC CodeInt. Cl.8: A01D 8/00, A01D 22/23, A01D 10/09, A01D 12/24, A01D 13/25, A01D 22/22, A01D 22/00
Abstract: In Ayurveda, Vaca (Acorus calamus, Family: Araceae), is reputed for its beneficial effects in various neurological disorders. The present investigation was undertaken to evaluate the role of 70% hydro-ethanolic extract of Vaca or Acorus calamus (ACE) on generalized anxiety disorder (GAD) in human. Hamilton’s Brief Psychiatric Rating Scale (BPRS) and thorough clinical investigations were used to screen the subjects. Thirty-three participants (20 male and 13 female; average age 36.2 yrs) were medicated with ACE in a fixed dose regime (500 mg/capsule, twice daily, p.o. after meal). They were thoroughly investigated clinically and using standard questionnaires based on different psychological rating scale at baseline (day 0), mid-term (day 30) and final (day 60). The scale also includes a number of direct queries about current levels of experienced stress. Moreover, the questions are of a general nature and hence are relatively free of content specific to any subpopulation group. The observations exhibited that, ACE not only significantly (p<0.001) attenuated anxiety related disorders but it also significantly (p<0.001) reduced stress phenomenon and its correlated depression. ACE further significantly (p<0.001) improved the willingness to adjustment. Therefore, it may be concluded that Vaca may be useful in the treatment of GAD in human and may be a promising anxiolytic agent in near future.
Page(s): 668-671
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Source:IJTK Vol.10(4) [October 2011]

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