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dc.contributor.authorSamarakoon, SMS-
dc.contributor.authorChandola, HM-
dc.contributor.authorRavishankar, B-
dc.contributor.authorAshok, BK-
dc.contributor.authorGupta, Varun B-
dc.identifier.issn0975-1068 (Online); 0972-5938 (Print)-
dc.description.abstractThe present study was undertaken to evaluate adaptogenic activity profile of a classical compound Ayurvedic formulation Amalakayas Rasayana in experimental animals. Amalakayas Rasayana (AR) was tested for its adaptogenic activity by determining anti-stress and anti-ulcer activity in forced swimming induced hypothermia and stress induced gastric ulcers. AR was administered in the dose of 270 mg/kg orally for 7 consecutive days prior to forced swimming induced hypothermia and stress ulcers. The adaptogenic and anti-ulcer activities were assessed by determining and comparing the changes in rectal temperature, ponderal changes, ulcer index, haematological parameters and anti-oxidant activity in the test drug group with that of stress control group as well as vehicle control group. In forced swimming hypothermia pre-treatment with AR caused significant attenuation of rectal temperature when compared with both stress control and vehicle control groups. It has shown a significant reduction in ulcer index and lipid peroxidation. Moreover, AR did show a significant increase in total glutathione content. The results suggest that AR possesses significant adaptogenic and anti-stress activity which could be either due to attenuation of stress induced stimulation of HPA axis and cytoprotective action of the test formulation.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.relation.ispartofseriesInt. Cl.8: H01R 25/00, G0L 1/00, A01D 20/48, A01D 20/76, A01D 7/12, A01D 4/52-
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJTK Vol.10(4) [October 2011]en_US
dc.subjectAmalakayas Rasayanaen_US
dc.subjectAdaptogenic activityen_US
dc.subjectUlcer indexen_US
dc.titleEvaluation of adaptogenic activity profile of a compound Ayurvedic formulation - Amalakayas Rasayanaen_US
Appears in Collections:IJTK Vol.10(4) [October 2011]

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