|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Traditional Knowledge (IJTK) >
IJTK Vol.10 [2011] >
IJTK Vol.10(4) [October 2011] >
| Title: | Evaluation of adaptogenic activity profile of a compound Ayurvedic formulation - Amalakayas Rasayana |
| Authors: | Samarakoon, SMS
Chandola, HM
Ravishankar, B
Ashok, BK
Gupta, Varun B |
| Keywords: | Amalakayas Rasayana
Adaptogenic activity
Ghrita
Madhu
Ulcer index |
| Issue Date: | Oct-2011 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. Cl.8: H01R 25/00, G0L 1/00, A01D 20/48, A01D 20/76, A01D 7/12, A01D 4/52 |
| Abstract: | The present study was undertaken to evaluate
adaptogenic activity profile of a classical compound Ayurvedic formulation Amalakayas Rasayana in experimental
animals. Amalakayas Rasayana (AR) was tested for its adaptogenic activity by
determining anti-stress and anti-ulcer activity in forced swimming induced
hypothermia and stress induced gastric ulcers. AR was administered in the dose
of 270 mg/kg orally for 7 consecutive days prior to forced swimming induced
hypothermia and stress ulcers. The adaptogenic and anti-ulcer activities were
assessed by determining and comparing the changes in rectal temperature,
ponderal changes, ulcer index, haematological parameters and anti-oxidant
activity in the test drug group with that of stress control group as well as
vehicle control group. In forced swimming hypothermia pre-treatment
with AR caused significant attenuation of rectal temperature when compared with
both stress control and vehicle control groups. It has shown a significant
reduction in ulcer index and lipid peroxidation. Moreover, AR did show a
significant increase in total glutathione content. The results suggest that AR possesses significant adaptogenic and anti-stress
activity which could be either due to attenuation of stress induced
stimulation of HPA axis and
cytoprotective action of the test formulation. |
| Page(s): | 661-667 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1068 (Online); 0972-5938 (Print) |
| Source: | IJTK Vol.10(4) [October 2011]
|
|
