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Indian Journal of Traditional Knowledge (IJTK) >
IJTK Vol.10 [2011] >
IJTK Vol.10(4) [October 2011] >
| Title: | Clinical evaluation of the hepatoprotective effect of Katuki (Picrorhiza kurroa Royle ex Benth.) processed in Guduchi (Tinospora cordifolia Wild.) Miers in patients receiving lipid lowering drugs (Statins) |
| Authors: | Singh, Harbans
Sharma, Y K |
| Keywords: | Drug induced hepatitis
Ayurveda
Hepatoprotective effect
Katuki
Guduchi
Statins |
| Issue Date: | Oct-2011 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. Cl.8: A01D 14/01, A01D 14/09, A01D 14/10, A01D 1/04, A01D 23/21, A01D 7/52 |
| Abstract: | The hypolipidaemic drugs have attracted
considerable attention because of their potential to prevent cardiovascular
disease by retarding the accelerated atherosclerosis in hyperlipidaemic
individuals. Statins are the first choice drugs for primary hyperlipidaemias
with raised LDL and total cholesterol levels, with or without raised
triglycerides levels, as well as for secondary hypercholesterolemia. Statin
therapy is commonly associated with liver damage in terms of elevated
aminotransaminases. Simultaneous use of
hepatotoxicity reducing formulation is desirable for successful continuation of
HMG-CoA reductase inhibitor (statins) over a desired period in hyperlipidaemic patients. So, the present
clinical study was planned to evaluate the hepatoprotective effect of Katuki (Picrorhiza kurroa Royle ex Benth.)
processed in Guduchi
[Tinospora cordifolia (Wild.)
Miers], on scientific parameters. In the present clinical
trial, two groups of patients receiving standardized lipid lowering drug
(Atrorvastatin 20 mg, twice daily) have been studied to evaluate the
hepatoprotective effect of these drugs. The first group was given
2 gm of Katuki processed in Guduchi, twice daily with statin
therapy. The second group was given 500 mg of starch powder filled in capsules,
twice daily with statin therapy. The trial was conducted for three months and
liver functions test were periodically evaluated to assess the hepatoprotective
effect of drugs under trial. At the end of the trial, trial group exhibited its
hepatoprotective efficiency over the control. |
| Page(s): | 657-660 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1068 (Online); 0972-5938 (Print) |
| Source: | IJTK Vol.10(4) [October 2011]
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