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Title: <i style="">Trans</i>-dichlorobis(<i style="">N-p</i>-tolylpyridin-2-amine)palladium(II): Synthesis, structure, fluorescence features and DNA binding
Authors: Kundu, Suman
Maity, Suvendu
Bhadra, Ranjan
Ghosh, Prasanta
Keywords: Density functional calculations
Fluorescence quenching
DNA binding
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
Abstract: Reaction of <i style="">N-p</i>-tolylpyridin-2-amine (<b style="">L<sup>Me</sup></b>)<b style=""> </b>with<b style=""> </b>H<sub>2</sub>PdCl<sub>4</sub> in boiling acetonitrile and ethanol solvents mixture (1:1) affords <i style="">trans</i>-Pd(<b style="">L<sup>Me</sup></b>)<sub>2</sub>Cl<sub>2</sub> (<b style="">1</b>) in high yield. (<b style="">1</b>) is substantiated by spectral data, single crystal X-ray structure determination, etc. Both (<b style="">L<sup>Me</sup></b>) and (<b style="">1</b>) absorb strongly in the UV region (<img src='/image/spc_char/lamda.gif' border=0> <sub>max</sub>, nm (<img src='/image/spc_char/italics_e.gif' border=0>, 10<sup>4 </sup><i style="">M</i><sup>–1</sup>cm<sup>–1</sup>), DCM: (<b style="">L<sup>Me</sup></b>), 310 (1.97), 276 (4.95); (<b style="">1</b>), 320 (4.36), 270 (6.98). (<b style="">L<sup>Me</sup></b>) is brightly fluorescent due to intra-ligand charge transfer singlet excited state (<img src='/image/spc_char/lamda.gif' border=0> <sub>ex</sub> = 332 nm, <img src='/image/spc_char/lamda.gif' border=0> <sub>em</sub> = 400 nm; <img src='/image/spc_char/phi.gif' border=0> = 0.621 measured with respect to anthracene) as elucidated by DFT and TD DFT calculations. In (<b style="">1</b>), the luminescence of (<b style="">L<sup>Me</sup></b>) is significantly (~ 97 %) quenched (<img src='/image/spc_char/phi.gif' border=0> = 0.016) and the fluorescence parameters are red shifted (<img src='/image/spc_char/lamda.gif' border=0> <sub>ex</sub> = 378 nm, <img src='/image/spc_char/lamda.gif' border=0> <sub>em</sub> = 430 nm). Binding of (<b style="">1</b>) to CT-DNA has been investigated by UV-vis spectrum confirming a significant interaction with the intrinsic binding constant as <i>K</i><sub>b </sub>= ~ 9.78 X 10<sup>5</sup> <i style="">M</i><sup>-1</sup> and CT-DNA-ethidium bromide fluorescence quenching experiment giving the apparent binding constant as <i>K</i><sub>app </sub>= 9.02 X 10<sup>5</sup> <i style="">M</i><i style=""> </i><sup>–1</sup>.
Description: 1443-1449
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.50A(09-10) [September-October 2011]

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