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Title: Type II Phosphatidylinositol 4-kinase(s) in Cell signaling Cascades
Authors: Sinha, Ranjeet Kumar
Subrahmanyam, Gosukonda
Keywords: Lipid kinases
Cell signaling
Cell adhesion
Microbial pathogenicity
Issue Date: Oct-2007
Publisher: CSIR
Abstract: Phosphorylated derivatives of phosphatidylinositol (PtdIns) are key components of many signaling cascades. Many isoforms of PtdIns kinases, PtdIns phosphate kinases and phosphatases use these lipids in amazing networks of signaling cascades that are yet to be understood fully. PtdIns 4-kinase(s) phosphorylates PtdIns at the 4th –OH position of inositol head group and are classified in to type II and III PtdIns 4-kinases. While type III PtdIns 4-kinases are implicated in vesicular trafficking, type II PtdIns 4-kinases are suggested to play a role in cell signaling, cytoskeletal rearrangements, cell motility and in microbial pathogenicity. This paper reviews the role of type II PtdIns 4-kinases in cell signaling cascades in health and disease.
Description: 289-294
ISSN: 0301-1208
Appears in Collections:IJBB Vol.44(5) [October 2007]

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