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Title: Synthesis and characterization of some gold(I)-thiolate complexes having N-methylimidazole moiety
Authors: Bhabak, Krishna P
Mugesh, Govindasamy
Keywords: Gold thiolate;Thiolates;Antithyroid drugs;Antiarthritic drugs;Methimazole;Ligand exchange;Rheumatoid arthritis
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
Abstract: Antithyroid drugs inhibit the thyroid hormone synthesis by inactivating the thyroid peroxidase and/or iodothyronine deiodinase, which are involved in iodination and deiodination reactions. Gold(I) compounds also inhibit the thyroid hormone synthesis by interacting with the selenocysteine residue of iodothyronine deiodinase. However, the chemical reactions between these two different classes of compounds have not been studied. In this paper, we describe the interaction of therapeutic gold(I) compounds with the commonly used thiourea-based antithyroid drug, methimazole. It is observed that the gold(I) phosphine complexes (R3PAuCl, where R = Me, Et, Ph) react with methimazole only upon deprotonation to produce the corresponding gold(I)-thiolate complexes. Addition of PPh3 to the gold(I)-thiolates produces (R3PAuPPh3)+ (R = Me or Et), indicating the possibility of ligand exchange reactions.
Page(s): 1303-1307
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.50A(09-10) [September-October 2011]

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