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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section A (IJC-A) >
IJC-A Vol.50A [2011] >
IJC-A Vol.50A(09-10) [September-October 2011] >
| Title: | Synthesis and characterization of some gold(I)-thiolate complexes having N-methylimidazole moiety |
| Authors: | Bhabak, Krishna P
Mugesh, Govindasamy |
| Keywords: | Gold thiolate
Thiolates
Antithyroid drugs
Antiarthritic drugs
Methimazole
Ligand exchange
Rheumatoid arthritis |
| Issue Date: | Sep-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Antithyroid drugs inhibit the thyroid
hormone synthesis by inactivating the thyroid peroxidase and/or iodothyronine
deiodinase, which are involved in iodination and deiodination reactions.
Gold(I) compounds also inhibit the thyroid hormone synthesis by interacting
with the selenocysteine residue of iodothyronine deiodinase. However, the
chemical reactions between these two different classes of compounds have not
been studied. In this paper, we describe the interaction of therapeutic gold(I)
compounds with the commonly used thiourea-based antithyroid drug, methimazole.
It is observed that the gold(I) phosphine complexes (R3PAuCl, where
R = Me, Et, Ph) react with methimazole only upon deprotonation
to produce the corresponding gold(I)-thiolate complexes. Addition of PPh3
to the gold(I)-thiolates produces (R3PAuPPh3)+
(R = Me or Et), indicating the possibility of ligand exchange reactions. |
| Page(s): | 1303-1307 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Source: | IJC-A Vol.50A(09-10) [September-October 2011]
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