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Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.2 [2011] >
IJNPR Vol.2(3) [September 2011] >
| Title: | Anti-inflammatory and analgesic activities of Dashana Samskara Churna and its paste form |
| Authors: | Peiris, K P P
Ashok, B K
Manjusha, R
Ravishankar, B |
| Keywords: | Analgesic
Anti-inflammatory
Carrageenan
Dashana Samskara Churna
Dental problems
Gingivitis |
| Issue Date: | Sep-2011 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | A61K 36/00, A61P 1/02, A61P 25/04, A61P 29/00 |
| Abstract: | Anti-inflammatory
and analgesic activities of Dashana Samskara Churna and its paste form
were examined in different animal models. Anti-inflammatory
activity was evaluated in acute, sub-acute and chronic inflammatory models and
compared with Phenylbutazone, Diclofenac sodium and Dexomethasone standards,
respectively. Analgesic activity was evaluated in formalin induced paw licking
(chemically induced pain) and tail flick method (thermally induced pain) where
Indomethacin and Pentazocine were used as standard drugs, respectively. Test
formulation in the form of paste inhibited the carrageenan induced paw oedema (P<0.05),
formalin induced paw licking (P<0.01) and increased the Tail Flick Latency
(P<0.05) in comparison to control rats. Test formulation in the form
of Churna did not inhibit the paw oedema induced by phlogostic agents,
however it exhibited significant analgesic activity by decreasing formalin
induced paw licking response (P<0.05). The results suggest that the
paste form of Dashana Samskara Churna
has significant analgesic and anti-inflammatory potential as reflected by the
parameters investigated, while Churna form has only analgesic activity.
Thus, it can be concluded that Dashana
Samskara Churna in the form of paste will be the most appropriate modality in
treatment of gingivitis. |
| Page(s): | 363-368 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1033 (Online); 0379-5136 (Print) |
| Source: | IJNPR Vol.2(3) [September 2011]
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