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Title: Hypoglycaemic activity of Coccinia indica Wight & Arn. fruits in Alloxan-induced diabetic rats
Authors: Ramakrishnan, M
Bhuvaneshwari, R
Duraipandiyan, V
Dhandapani, R
Keywords: Alloxan;Coccinia indica;Diabetes;Fruits;Glibenclamide;Hypoglycaemic
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
IPC Code: A61K 36/42, A61K 131/00, A61P 3/10
Abstract: Fruit extracts of Coccinia indica Wight & Arn. were evaluated for their antidiabetic activity in Alloxan-induced diabetic rats. Diabetes was induced in experimental rats by a single intraperitoneal injection of alloxan monohydrate (150 mg/kg body wt). Ethanol, chloroform and aqueous extracts of C. indica fruits were administered orally at a dose of 250 mg/kg body wt to diabetic rats. Blood glucose was analysed using glucose oxidase-peroxidase reactive strips. Significant antidiabetic activity was observed in ethanolic extract in terms of reduction of fasting blood glucose level in diabetic rats. After 7 h blood glucose was depressed by 8.2% (P < 0.05) and 10.06% (P < 0.01) in alloxan-induced diabetic rats. The effect of the ethanolic extract particularly at 250 mg/kg was comparable to that of standard drug Glibenclamide (1 mg/kg body wt).
Page(s): 350-353
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Appears in Collections:IJNPR Vol.2(3) [September 2011]

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