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Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.2 [2011] >
IJNPR Vol.2(3) [September 2011] >
| Title: | Studies on inhibitory effect of Eucalyptus oil on sebaceous glands for the management of acne |
| Authors: | Bhatt, Deepika
Sachan, Amit Kumar
Jain, Sanjay
Barik, Rakesh |
| Keywords: | Acne
Antibacterial
Eucalyptus globulus
Eucalyptus oil
Sebaceous glands
Sebum |
| Issue Date: | Sep-2011 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | A61K 36/61, A61P 17/10, A61P 31/04 |
| Abstract: | Acne
is the most common disorder virtually seen to affect teenagers and young
adults between age of 14-30. It is characterized by inflamed specialized
sebaceous follicles which are present at face, back and chest. Some serious
factors responsible for generation of acne are abnormal follicular
keratinization and desquamation, excessive secretion of sebum, and
proliferation of Propionibacterium acnes in follicles. Other factors
aggravating or worsening the acne conditions are secondary infections caused by
some pathogenic strains of bacteria like Staphylococcus aureus, Pseudomonas
aeruginosa, Escherichia coli, etc. There
are various topical and systemic therapies available in market to treat or
control the acne but maximum of them have the side effects like itching,
redness, skin peeling, stinging and photosensitivity. Again, the development of
resistance of available antibiotics for P. acne and other bacterial strains
has necessitated the search for new antimicrobial agents. Thus, the current
work was designed to gain attention towards the alternate pathway for
controlling the acne condition by decreasing the production of sebum from
sebaceous glands. The eucalyptus oil, obtained from Eucalyptus globulus Labill.
(Myrtaceae) was chosen and its biocide action on various bacterial strains was
established using agar-well diffusion technique to prove its efficacy in
controlling the secondary infection condition i.e. worsening of acnes. The in
vivo rat sebaceous gland model was chosen to show the effectiveness of
eucalyptus oil in decreasing the sebum production by reducing the size of
sebaceous glands to control the spread of acne. The results were found to be
promising for eucalyptus oil in controlling the sebum protection and thus
establishing the other pathway for the management of acne. |
| Page(s): | 345-349 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1033 (Online); 0379-5136 (Print) |
| Source: | IJNPR Vol.2(3) [September 2011]
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