19-Jun-2013
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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.2 [2011] >
IJNPR Vol.2(3) [September 2011] >
| Title: | A comparative evaluation of cardioprotective activity of two Makandi (Coleus forskohlii Willd.) formulations against isoproterenol induced myocardial infarction in hyperlipidaemic rats |
| Authors: | Jagtap, Madhavi
Ashok, B K
Chavan, Sulakshan S
Chandola, H M
Ravishankar, B |
| Keywords: | Cardioprotective
Coleus forskohlii
Hyperlipidaemia
Makandi
Makandi churna
Makandi ghanavati
Myocardial infarction |
| Issue Date: | Sep-2011 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | A61K 36/53, A61K 125/00, A61P 9/00 |
| Abstract: | The present study was undertaken to evaluate cardioprotective activity of Makandi
(Coleus forskohli Willd.) Churna and Ghanavati
on the basis of electrocardiographic, biochemical, cardiac output and
histopathological parameters against isoproterenol (ISO) induced myocardial
infarction in
diet induced hyperlipidaemic rats. The drug treatment and hyperlipidaemic diets
were administered for 20 consecutive days. Myocardial injury was induced
by injecting ISO
(85 mg/kg) to rats at an interval of 24 h for two days. Forty eight hours after
the first dose of ISO injection, parameters like ECG, cardiac output,
biochemical and histological observations of the heart tissues were performed.
Hyperlipidaemic diet followed by ISO significantly increased heart weight,
altered serum lipid profiles, SGPT and ALP activity, caused ST segment
elevation, prolonged QT interval and QTc in ECG, increased blood pressure and
decreased cardiac output. Histopathologically also, heart showed severe
cytoarchitectural disturbances like myonecrosis,
fatty changes and endocardial oedema. When administered orally, both the
formulations of Makandi decreased atherogenic index, almost normalized
ST segment elevation, QT interval prolongation and cardiac output.
Histopathologically also remarkable protection was observed. Analysis of the
results showed that Makandi in Churna form has both
anti-atherogenic potential and cardioprotective activity, while Ghanavti
has only weak cardioprotective activity. |
| Page(s): | 335-344 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1033 (Online); 0379-5136 (Print) |
| Source: | IJNPR Vol.2(3) [September 2011]
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