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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.2 [2011] >
IJNPR Vol.2(3) [September 2011] >
| Title: | A comparative study of in vitro antioxidant and DNA damage protection of soxhlet vs microwave assisted extracts of Michelia champaca Linn. flowers |
| Authors: | Jaishree, V
Shabna, V |
| Keywords: | Michelia champaca
Antioxidant activity
DNA damage protection |
| Issue Date: | Sep-2011 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | A61K 36/00 |
| Abstract: | Present study
was designed to compare antioxidant and DNA damage protection of Soxhlet
assisted (80% methanol) extract (SEMC) with microwave assisted (80% methanol)
extract of Michelia champaca Linn.
(MEMC). The in vitro antioxidant activity of SEMC and MEMC
were tested for DPPH, hydroxyl radical (OH) by deoxyribose, lipid peroxidation
and reducing power capacity. The extracts were also tested for protection
against hydroxyl radical and tertiary butylated peroxide (t-BOOH) radical
mediated DNA damage. SEMC showed highest percentage of inhibition in all the
concentrations in DPPH assay. Both SEMC and MEMC showed better percentage of
inhibition 93.0 and 85.0%, respectively, at 50 µg/ml concentration in hydroxyl
radical assay. In lipid peroxidation inhibition assay both extracts have shown
good peroxidation inhibition activity. In reducing power assay SEMC showed
highest power of reduction. MEMC exhibited good protection against hydroxyl
radical and t-BOOH mediated damage to DNA. |
| Page(s): | 330-334 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1033 (Online); 0379-5136 (Print) |
| Source: | IJNPR Vol.2(3) [September 2011]
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