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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.2 [2011] >
IJNPR Vol.2(3) [September 2011] >
| Title: | Antioxidant efficacy of endocarp with kernel of Ziziphus mauritiana Lam. in p-dimethylaminoazobenzene induced hepatocarcinoma in Rattus norvigicus |
| Authors: | Kalidoss, A
Krishnamoorthy, P |
| Keywords: | Ziziphus mauritiana
Indian jujube
Ber
p-Dimethylaminoazobenzene
Phenobarbital
Endocarp
Antioxidants |
| Issue Date: | Sep-2011 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | A61K 36/00, A61P 17/18 |
| Abstract: | Carcinogens, 0.06% of p-dimethylaminoazobenzene
(p-DAB) with feed and 0.05% phenobarbital
(PB) with water were orally administered to rats for 60 days. Powdered
endocarps of Ziziphus mauritiana Lam.
were extracted with two different solvents, ethanol and ethylacetate. Oral LD50
of the two extracts were estimated to be 1200.24 mg/kg body weight. Preliminary
phytochemical studies of the extracts revealed the presence of triterpenoids,
reducing sugars, sugars, alkaloids, phenolics, catechins, flavonoids, saponins,
tannins and amino acids. Experimental rats were orally co-fed with the ethanol
extract (at two different doses of 300 and 150 mg/kg/bw) and carcinogens.
Comparatively, other group was co-fed with ethylacetate extract (at two
different doses of 300 and 150mg/kg/b.w) with carcinogens. Antioxidant
biochemical studies revealed that ethanol extract was more effective than
ethylacetate extract. Histological studies revealed a distinct hepatoprotective
effect of Z. mauritiana endocarps
(with kernel) at 300 mg/kg body weight of ethanol extract, which sustained the
normal architecture of liver cells from p-Dimethtylaminoazobenzene
and phenobarbitol induced toxicity, whereas severe damages were evident in the
hepatocarcinoma induced rats. |
| Page(s): | 307-314 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| Source: | IJNPR Vol.2(3) [September 2011]
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