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Title: Antioxidant efficacy of endocarp with kernel of Ziziphus mauritiana Lam. in p-dimethylaminoazobenzene induced hepatocarcinoma in Rattus norvigicus
Authors: Kalidoss, A
Krishnamoorthy, P
Keywords: Ziziphus mauritiana;Indian jujube;Ber;p-Dimethylaminoazobenzene;Phenobarbital;Endocarp;Antioxidants
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
IPC Code: A61K 36/00, A61P 17/18
Abstract: Carcinogens, 0.06% of p-dimethylaminoazobenzene (p-DAB) with feed and 0.05% phenobarbital (PB) with water were orally administered to rats for 60 days. Powdered endocarps of Ziziphus mauritiana Lam. were extracted with two different solvents, ethanol and ethylacetate. Oral LD50 of the two extracts were estimated to be 1200.24 mg/kg body weight. Preliminary phytochemical studies of the extracts revealed the presence of triterpenoids, reducing sugars, sugars, alkaloids, phenolics, catechins, flavonoids, saponins, tannins and amino acids. Experimental rats were orally co-fed with the ethanol extract (at two different doses of 300 and 150 mg/kg/bw) and carcinogens. Comparatively, other group was co-fed with ethylacetate extract (at two different doses of 300 and 150mg/kg/b.w) with carcinogens. Antioxidant biochemical studies revealed that ethanol extract was more effective than ethylacetate extract. Histological studies revealed a distinct hepatoprotective effect of Z. mauritiana endocarps (with kernel) at 300 mg/kg body weight of ethanol extract, which sustained the normal architecture of liver cells from p-Dimethtylaminoazobenzene and phenobarbitol induced toxicity, whereas severe damages were evident in the hepatocarcinoma induced rats.
Page(s): 307-314
Appears in Collections:IJNPR Vol.2(3) [September 2011]

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