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|Title:||Antioxidant efficacy of endocarp with kernel of<i style=""> Ziziphus mauritiana</i> Lam. in <i style="">p</i>-dimethylaminoazobenzene induced hepatocarcinoma in <i style="">Rattus norvigicus</i>|
|Keywords:||<i style="">Ziziphus mauritiana</i>|
|Series/Report no.:||A61K 36/00, A61P 17/18|
|Abstract:||Carcinogens, 0.06% of <i style="">p</i>-dimethylaminoazobenzene (<i style="">p</i>-DAB) with feed and 0.05% phenobarbital (PB) with water were orally administered to rats for 60 days. Powdered endocarps of <i style="">Ziziphus mauritiana</i> Lam. were extracted with two different solvents, ethanol and ethylacetate. Oral LD<sub>50</sub> of the two extracts were estimated to be 1200.24 mg/kg body weight. Preliminary phytochemical studies of the extracts revealed the presence of triterpenoids, reducing sugars, sugars, alkaloids, phenolics, catechins, flavonoids, saponins, tannins and amino acids. Experimental rats were orally co-fed with the ethanol extract (at two different doses of 300 and 150 mg/kg/bw) and carcinogens. Comparatively, other group was co-fed with ethylacetate extract (at two different doses of 300 and 150mg/kg/b.w) with carcinogens. Antioxidant biochemical studies revealed that ethanol extract was more effective than ethylacetate extract. Histological studies revealed a distinct hepatoprotective effect of <i style="">Z. mauritiana</i> endocarps (with kernel) at 300 mg/kg body weight of ethanol extract, which sustained the normal architecture of liver cells from <i style="">p</i>-Dimethtylaminoazobenzene and phenobarbitol induced toxicity, whereas severe damages were evident in the hepatocarcinoma induced rats.|
|Appears in Collections:||IJNPR Vol.2(3) [September 2011]|
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