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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.48 [2011] >
IJBB Vol.48(4) [August 2011] >
| Title: | HSP70 Expression and its Role in Preeclamptic Stress |
| Authors: | Ekambaram, Padmini |
| Keywords: | Preeclampsia
HSP70
Stress
Mint-tea
Ureaplasma urealyticum |
| Issue Date: | Aug-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Preeclampsia,
a hypertensive pregnancy-specific disorder, has long been analyzed for its
association with cellular stress. It still remains one of the most serious
complications of pregnancy. It is a multi-system disorder that affects maternal
vascular function and fetal growth. The physiopathology of preeclampsia is
still unclear, but an imbalance between reactive oxygen species (ROS) and
antioxidants, appears to be an important contributing factor. Oxidative stress
has been increasingly postulated as a major contributor to endothelial
dysfunction in preeclampsia (PE). The ROS promotes lipid oxidation and are
known to induce stress proteins, such as hemeoxygenase 1 (HO-1) and heat-shock
protein 70 (HSP70). Embryonic and placental cells are highly sensitive to oxidative
stress due to their proliferate nature. Endothelial cell dysfunction is
suggested to be a part of wider maternal inflammatory reaction responsible for
the clinical syndrome of preeclampsia. Part of the dysfunction in endothelial
cell and trophoblast is attributed to oxidative stress developed during
pregnancy. The disequilibrium in compensatory antioxidant control is proposed
as a causative mechanism in the pathophysiology of preeclampsia. HSP70 acts as
the secondary line of defense in systems with compromised antioxidant function.
This article reviews the differential expression of HSP70 and the effect of
mint-tea therapy to modulate preeclamptic oxidative damage. |
| Page(s): | 243-255 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.48(4) [August 2011]
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