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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.48 [2011] >
IJBB Vol.48(4) [August 2011] >
| Title: | Molecular Interaction between the Glucocorticoid Receptor and MAPK Signaling Pathway: A novel link in Modulating the Anti-inflammatory Role of Glucocorticoids |
| Authors: | Kharwanlang, Banteiskhem
Sharma, Ramesh |
| Keywords: | Glucocorticoids
Glucocorticoid receptor
MAPK signaling
Molecular interaction
Anti-inflammatory |
| Issue Date: | Aug-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Glucocorticoids (GCs) have a broad spectrum
of life-sustaining functions and play an important role in health and diseases.
At pharmacologic doses, GCs are potent immunosuppressive and anti-inflammatory
agents. Inflammation and its related diseases present a huge ever
increasing burden on the health and disease management. A plausible link of inflammation
with aging, cardiovascular diseases and cancer makes matter even worst and calls
for a better understanding to resolve the mechanisms associated with the cause
and cure of inflammation. Understanding the physiological and molecular
interlinks is an utmost importance in designing novel therapeutic strategies in
combating inflammation. Advancement in research related to the mitogen-activated
protein kinase (MAPK) signaling pathway and its regulation on inflammation has
open up new and promising avenues in targeting inflammation as well as
understanding the anti-inflammatory property of GCs. Molecular interaction
between the ligand-activated glucocorticoid receptor (GR) and the MAPK
signaling at different junctions inhibit the latter and thus may account for
the anti-inflammatory role of GCs. Therapeutic application of GCs in
combination with the recently added class of GR modulators having greater
transrepresssion over transactivation (dissociative property) might overcome
the clinical side effects associated with GCs. |
| Page(s): | 236-242 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.48(4) [August 2011]
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