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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.48 [2011] >
IJBB Vol.48(4) [August 2011] >
| Title: | Early Growth Response 1— A Transcription Factor in the crossfire of Signal Transduction Cascades |
| Authors: | Pagel, Judith-Irina
Deindl, Elisabeth |
| Keywords: | Egr-1
MEK/ERK
Serum response factor
Transcription factor
Rho-kinase
Signal transduction cascades |
| Issue Date: | Aug-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Early growth response-1 (Egr-1) is a
Cys2-His2-type zinc-finger transcription factor. A broad range of extracellular
stimuli is capable of activating Egr-1, thus mediating growth, proliferation,
differentiation or apoptosis. Egr-1 is, therefore, participating in the
progression of a variety of diseases such as atherosclerosis or cancer.
Functional response elements connect Egr-1 to signal transduction cascades
targeting Egr-1. Five serum response elements (SRE) have been identified in the
promoter region of Egr-1, the binding region of serum response factor (SRF).
The Rho/Rho-kinase pathway has been shown to regulate actin reorganization via
LIM-kinase mediated cofilin phosphorylation. Recent studies have revealed that
the actin binding striated muscle activator of Rho signaling (STARS) promotes translocation
of myosin related transcription factors (MRTFs) into the nucleus, leading to
SRF activation. The ternary complex factor (TCF) Elk-1 eventually bridges the
gap between SRF-mediated gene transcription and the Raf/MEK/ERK pathway.
Moreover, the Egr-1 promoter owns two cAMP response elements (CREs), whose
relevance for gene expression is still unclear. An Egr-1 binding site (EBS)
located on the Egr-1 promoter itself is arguing for a negative feedback
mechanism. The acquired knowledge on transcriptional regulation of Egr-1 is not
entirely understood. In this review, we highlight upstream and downstream
signaling in vitro and in vivo associated with Egr-1. |
| Page(s): | 226-235 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.48(4) [August 2011]
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