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|Title:||Two charge-transfer complexation reactions for spectrophotometric determination of pheniramine maleate using -acceptors|
|Authors:||Raghu, M S|
|Keywords:||Charge-transfer (CT) complexation;Pharmaceuticals;Pheniramine maleate (PAM);Spectrophotometry|
|Abstract:||This study presents two simple, selective and rapid spectrophotometric methods for determination of pheniramine maleate (PAM) in pure form and in its formulations. Both methods are based on the formation of charge-transfer (CT) reaction of PAM with p-chloranilic acid (CAA) or 2,3-dichloro-5,6-dicyanoquinone (DDQ) in 1,4-dioxan-acetonitrile medium. CT complexes were quantified at 530 and 590 nm for CAA and DDQ methods, respectively. Beer’s law is obeyed (conc. ranges, 12.5-200 μg ml-1 for CAA and 5-80 μg ml-1 for DDQ method), with correlation coefficients (r) of 0.9999 and 0.9991. Apparent molar absorptivities are calculated to be 1.27×103 and 3.06×103 l mol-1cm-1, respectively and corresponding Sandell sensitivities are 0.281 and 0.112 μg cm-2. Developed methods were successfully applied for determination of PAM in tablets and injections.|
|ISSN:||0975-1084 (Online); 0022-4456 (Print)|
|Appears in Collections:||JSIR Vol.70(10) [October 2011]|
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