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JSIR Vol.70 [2011] >
JSIR Vol.70(10) [October 2011] >
| Title: | Two charge-transfer complexation reactions for spectrophotometric determination of pheniramine maleate using  -acceptors |
| Authors: | Raghu, M S
Basavaiah, K |
| Keywords: | Charge-transfer (CT) complexation
Pharmaceuticals
Pheniramine maleate (PAM)
Spectrophotometry |
| Issue Date: | Oct-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | This study presents two
simple, selective and rapid spectrophotometric methods for determination of
pheniramine maleate
(PAM) in pure form and in its
formulations. Both methods are based on the formation of charge-transfer (CT)
reaction of PAM
with p-chloranilic acid (CAA)
or 2,3-dichloro-5,6-dicyanoquinone (DDQ) in 1,4-dioxan-acetonitrile medium. CT
complexes were
quantified at 530 and 590 nm
for CAA and DDQ methods, respectively. Beer’s law is obeyed (conc. ranges,
12.5-200 μg ml-1 for
CAA and 5-80 μg ml-1 for DDQ
method), with correlation coefficients (r) of 0.9999 and 0.9991. Apparent molar
absorptivities are
calculated to be 1.27×103 and
3.06×103 l mol-1cm-1, respectively and corresponding Sandell sensitivities are
0.281 and 0.112 μg cm-2.
Developed methods were
successfully applied for determination of PAM in tablets and injections. |
| Page(s): | 851-858 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Source: | JSIR Vol.70(10) [October 2011]
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