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|Title:||Synthesis and biological evaluation of Mannich bases of benzimidazole derivatives|
Bhuyan, N R
|Abstract:||[1-(N-substituted amino) methyl]-2-ethyl benzimidazole derivatives <b style="">1-10</b> have been<b style=""> </b>synthesized by the condensation of 2-ethyl benzimidazole with substituted primary and secondary amines. Their structures have been elucidated by UV-Vis, IR, <sup>1</sup>H NMR and mass spectral data. Among the synthesized derivatives <b style="">1, 2, 8, 9</b> and <b style="">10</b> are found to have an effective anti-inflammatory response whereas compounds <b style="">2, 4, 6, 8</b> and <b style="">10</b> have potent analgesic response. There is no significant difference in bioactivity of benzimidazoles derived from secondary and primary amines. All the experimental data were statistically significant at P<0.05 level.|
|Appears in Collections:||IJC-B Vol.50B(09) [September 2011]|
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