NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(09) [September 2011] >


Title: Synthesis and biological evaluation of Mannich bases of benzimidazole derivatives
Authors: Mariappan, G
Bhuyan, N R
Kumar, Pradeep
Kumar, Deepak
Murali, K
Keywords: Benzimidazole
Analgesic
Anti-inflammatory
Mannich bases
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
Abstract: [1-(N-substituted amino) methyl]-2-ethyl benzimidazole deriĀ­vatives 1-10 have been synthesized by the condensation of 2-ethyl benzimidazole with substituted primary and secondary amines. Their structures have been elucidated by UV-Vis, IR, 1H NMR and mass spectral data. Among the synthesized derivatives 1, 2, 8, 9 and 10 are found to have an effective anti-inflammatory response whereas compounds 2, 4, 6, 8 and 10 have potent analgesic response. There is no significant difference in bioactivity of benzimidazoles derived from secondary and primary amines. All the experimental data were statistically significant at P<0.05 level.
Page(s): 1216-1219
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.50B(09) [September 2011]

Files in This Item:

File Description SizeFormat
IJCB 50B(9) 1216-1219.pdf64.88 kBAdobe PDFView/Open
 Current Page Visits: 1039 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 586446 since 06-Feb-2009  Last updated on 18-Sep-2014Webmaster: nopr@niscair.res.in