Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/12674
Title: Synthesis and biological evaluation of Mannich bases of benzimidazole derivatives
Authors: Mariappan, G
Bhuyan, N R
Kumar, Pradeep
Kumar, Deepak
Murali, K
Keywords: Benzimidazole
Analgesic
Anti-inflammatory
Mannich bases
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
Abstract: [1-(N-substituted amino) methyl]-2-ethyl benzimidazole deriĀ­vatives <b style="">1-10</b> have been<b style=""> </b>synthesized by the condensation of 2-ethyl benzimidazole with substituted primary and secondary amines. Their structures have been elucidated by UV-Vis, IR, <sup>1</sup>H NMR and mass spectral data. Among the synthesized derivatives <b style="">1, 2, 8, 9</b> and <b style="">10</b> are found to have an effective anti-inflammatory response whereas compounds <b style="">2, 4, 6, 8</b> and <b style="">10</b> have potent analgesic response. There is no significant difference in bioactivity of benzimidazoles derived from secondary and primary amines. All the experimental data were statistically significant at P&lt;0.05 level.
Description: 1216-1219
URI: http://hdl.handle.net/123456789/12674
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(09) [September 2011]

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