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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(09) [September 2011] >
| Title: | Synthesis and biological evaluation of Mannich bases of benzimidazole derivatives |
| Authors: | Mariappan, G
Bhuyan, N R
Kumar, Pradeep
Kumar, Deepak
Murali, K |
| Keywords: | Benzimidazole
Analgesic
Anti-inflammatory
Mannich bases |
| Issue Date: | Sep-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | [1-(N-substituted amino)
methyl]-2-ethyl benzimidazole derivatives 1-10
have been synthesized by the
condensation of 2-ethyl benzimidazole with substituted primary and secondary
amines. Their structures have been elucidated by UV-Vis, IR, 1H NMR
and mass spectral data. Among the synthesized derivatives 1, 2, 8, 9 and 10 are
found to have an effective anti-inflammatory response whereas compounds 2, 4, 6, 8 and 10 have potent analgesic response. There is no significant difference in bioactivity of benzimidazoles
derived from secondary and primary amines. All the experimental data were statistically significant at P<0.05
level. |
| Page(s): | 1216-1219 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(09) [September 2011]
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