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Title: Synthesis and biological evaluation of Mannich bases of benzimidazole derivatives
Authors: Mariappan, G
Bhuyan, N R
Kumar, Pradeep
Kumar, Deepak
Murali, K
Keywords: Benzimidazole;Analgesic;Anti-inflammatory;Mannich bases
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
Abstract: [1-(N-substituted amino) methyl]-2-ethyl benzimidazole deriĀ­vatives 1-10 have been synthesized by the condensation of 2-ethyl benzimidazole with substituted primary and secondary amines. Their structures have been elucidated by UV-Vis, IR, 1H NMR and mass spectral data. Among the synthesized derivatives 1, 2, 8, 9 and 10 are found to have an effective anti-inflammatory response whereas compounds 2, 4, 6, 8 and 10 have potent analgesic response. There is no significant difference in bioactivity of benzimidazoles derived from secondary and primary amines. All the experimental data were statistically significant at P<0.05 level.
Page(s): 1216-1219
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(09) [September 2011]

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