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IJC-B Vol.50B(09) [September 2011] >

Title: Synthesis and antibacterial activity of some novel N-substituted 3-[4-(1-alkyl/acyl/aroyl-1H-benzimidazol-2-yl)phenyl]acrylate derivatives
Authors: Chaudhari, Raju B
Vaidya, Sanjay D
Karale, B K
Pawar, P Y
Rindhe, Sahebrao S
Keywords: Benzimidazole
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
Abstract: Synthesis of a series of novel 3-[4-(1-alkyl/acyl/aroyl-1H-benzimidazol-2-yl)phenyl]acrylate derivatives has been reported. These derivatives are prepared by condensation of o-phenyle¬≠nediamine with 4-bromobenzoic acid to give 2-(4-bromophenyl)-1H-benzimidazole which undergoes Heck reaction with alkyl acrylates to give the above benzimidazole derivatives. Subsequent reactions of these compounds with different types of electrophiles afford a series of the corresponding 1N-substituted alkyl/acyl/¬≠aroyl/sulfonyl derivatives. Furthermore, the antibacterial activities of these compounds have been checked against Staphylococcus aureus and Salmonella typhimurium bacterial strains but the results are found to be disappointing.
Page(s): 1208-1215
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.50B(09) [September 2011]

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