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Title: | Synthesis and antibacterial activity of some novel N-substituted 3-[4-(1-alkyl/acyl/aroyl-1H-benzimidazol-2-yl)phenyl]acrylate derivatives |
Authors: | Chaudhari, Raju B Vaidya, Sanjay D Karale, B K Pawar, P Y Rindhe, Sahebrao S |
Keywords: | Benzimidazole;Heck;Acrylate;Antibacterial |
Issue Date: | Sep-2011 |
Publisher: | NISCAIR-CSIR, India |
Abstract: | Synthesis of a series of novel 3-[4-(1-alkyl/acyl/aroyl-1H-benzimidazol-2-yl)phenyl]acrylate derivatives has been reported. These derivatives are prepared by condensation of o-phenylenediamine with 4-bromobenzoic acid to give 2-(4-bromophenyl)-1H-benzimidazole which undergoes Heck reaction with alkyl acrylates to give the above benzimidazole derivatives. Subsequent reactions of these compounds with different types of electrophiles afford a series of the corresponding 1N-substituted alkyl/acyl/aroyl/sulfonyl derivatives. Furthermore, the antibacterial activities of these compounds have been checked against Staphylococcus aureus and Salmonella typhimurium bacterial strains but the results are found to be disappointing. |
Page(s): | 1208-1215 |
URI: | http://hdl.handle.net/123456789/12673 |
ISSN: | 0975-0983(Online); 0376-4699(Print) |
Appears in Collections: | IJC-B Vol.50B(09) [September 2011] |
Files in This Item:
File | Description | Size | Format | |
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IJCB 50B(9) 1208-1215.pdf | 91.78 kB | Adobe PDF | View/Open |
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