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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(09) [September 2011] >
| Title: | Synthesis and antibacterial activity of some novel N-substituted 3-[4-(1-alkyl/acyl/aroyl-1H-benzimidazol-2-yl)phenyl]acrylate derivatives |
| Authors: | Chaudhari, Raju B
Vaidya, Sanjay D
Karale, B K
Pawar, P Y
Rindhe, Sahebrao S |
| Keywords: | Benzimidazole
Heck
Acrylate
Antibacterial |
| Issue Date: | Sep-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Synthesis of a series of novel 3-[4-(1-alkyl/acyl/aroyl-1H-benzimidazol-2-yl)phenyl]acrylate
derivatives has been reported.
These derivatives are prepared by condensation of o-phenylenediamine with 4-bromobenzoic acid to give
2-(4-bromophenyl)-1H-benzimidazole which undergoes Heck reaction with
alkyl acrylates to give the above benzimidazole derivatives. Subsequent reactions of these
compounds with different types of electrophiles afford a series of the
corresponding 1N-substituted alkyl/acyl/aroyl/sulfonyl derivatives.
Furthermore, the antibacterial activities of these compounds have been checked
against Staphylococcus aureus and Salmonella typhimurium bacterial
strains but the results are found to be disappointing. |
| Page(s): | 1208-1215 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(09) [September 2011]
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