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Title: Design, facile synthesis and biological evaluation of quinazoline containing pyrazolothiazolyl, triazinone and their ethoxyphthalimide derivatives
Authors: Dangi, Raja Ram
Hussain, Nasir
Joshi, Ajit
Pemawat, Gangotri
Talesara, Ganpat Lal
Keywords: Benzoxazine
Schiff base
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of 3-(4-substituted benzylidene)-4-N-ethoxyphthalimido-6-phenyl-3,4-dihydro-2<i>H</i>-[1,2,4]triazino[2,3-<i>c</i>]quinazolin-2-one <b style="">6a-d</b> and 3-[3-(4-substituted benzylidene-5-phenyl- 2-N-ethoxyphthalimido-3,3<i style="">a</i>-dihydro-2<i>H</i>-pyrazolo[3,4-<i>d</i>][1,3]thiazol-6(5<i>H</i>)-yl)]-2-phenylquinazolin-4(3<i>H</i>)-one <b style="">11a-d</b> have been designed and synthesized starting from benzoxazine <b style="">1</b>. The structure of all synthesized compounds has been established by IR, <sup>1</sup>H and <sup>13</sup>C NMR and mass spectral studies. These compounds have been screened for antimicrobial activities in order to evaluate the possibility of the derivatives to be used as potential chemotherapeutic agents.
Description: 1165-1172
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(09) [September 2011]

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