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Title: Design, facile synthesis and biological evaluation of quinazoline containing pyrazolothiazolyl, triazinone and their ethoxyphthalimide derivatives
Authors: Dangi, Raja Ram
Hussain, Nasir
Joshi, Ajit
Pemawat, Gangotri
Talesara, Ganpat Lal
Keywords: Benzoxazine;Quinazoline;Pyrazole;Schiff base;Bromoethoxyphthalimide
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of 3-(4-substituted benzylidene)-4-N-ethoxyphthalimido-6-phenyl-3,4-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-one 6a-d and 3-[3-(4-substituted benzylidene-5-phenyl- 2-N-ethoxyphthalimido-3,3a-dihydro-2H-pyrazolo[3,4-d][1,3]thiazol-6(5H)-yl)]-2-phenylquinazolin-4(3H)-one 11a-d have been designed and synthesized starting from benzoxazine 1. The structure of all synthesized compounds has been established by IR, 1H and 13C NMR and mass spectral studies. These compounds have been screened for antimicrobial activities in order to evaluate the possibility of the derivatives to be used as potential chemotherapeutic agents.
Page(s): 1165-1172
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(09) [September 2011]

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