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|Title:||Effect of substituents on enantioselectivity in chiral oxazaborolidine mediated asymmetric ketone reduction reaction|
Prochiral ketone reduction
|Abstract:||Various new chiral ligands have been synthesized by the condensation of different esters of l-Valine with different substituted salicylaldehydes in order to find the most effective catalyst for the enantioselctive ketone reduction. Chiral amine synthesized from l-Valine methyl ester and 5-chloro salicylaldehyde is found to catalyse the enantioselective reduction of prochiral ketone with high yield (99%) and enantiomeric excess (91%) with 20 mol% of the catalyst using borane dimethylsulphide as a stoichiometric reducutant. Different subsituted prochiral ketones have also been reduced in high yield upto 90% and the corresponding secondary alcohols are formed with good enantiomeric excess upto 99%. The mechanism of this reduction can be very well explained by considering a plausible mechanism for the CBS catalyst.|
|Appears in Collections:||IJC-B Vol.50B(09) [September 2011]|
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