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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(09) [September 2011] >
| Title: | Protection against radiation clastogenecity in mouse bone marrow by Phyllanthus niruri |
| Authors: | Thakur, Indu
Devi, P Uma
Bigoniya, Papiya |
| Keywords: | Chromosome protection
Gamma irradiation
Mouse bone marrow
Phyllanthus niruri |
| Issue Date: | Sep-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The effects of aqueous (PnAq) and alcoholic (PnAl)
extract (50-250 mg/kg) of P. niruri on in vivo gamma radiation induced chromosome aberration and in vitro antioxidant activity (50-500
µg/ml) were studied. The antioxidant activity was studied by measuring
inhibition of hydroxyl radicals generated by the fenton reaction along with
pro-oxidant and iron chelating ability. PnAl showed highly significant in vitro free radical scavenging ability
when compared to DMSO above
250 µg/ml concentration. PnAq showed significant pro-oxidant activity while
PnAl was devoid of it at the tested concentrations. Exposure to gamma radiation
(4 Gy) caused 29.10 % increase in the frequency of chromosomal aberrations. Administration
of PnAl (250 mg/kg) showed highly significant decrease in chromosomal
aberrations compared to radiation treated group. Radioprotective potential of
alcoholic extract was found to be more effective than the aqueous extract. Qualitative
phytochemical investigation of PnAq and PnAl revealed the presence of sugars,
flavonoids, alkaloid, lignans, polyphenols, tannins, coumarins and saponins. Higher
radioprotective effect of the alcoholic extract may be attributed to rich
presence of antioxidant polyphenolic compounds. |
| Page(s): | 704-710 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(09) [September 2011]
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