NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(09) [September 2011] >


Title: Protection against radiation clastogenecity in mouse bone marrow by Phyllanthus niruri
Authors: Thakur, Indu
Devi, P Uma
Bigoniya, Papiya
Keywords: Chromosome protection
Gamma irradiation
Mouse bone marrow
Phyllanthus niruri
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
Abstract: The effects of aqueous (PnAq) and alcoholic (PnAl) extract (50-250 mg/kg) of P. niruri on in vivo gamma radiation induced chromosome aberration and in vitro antioxidant activity (50-500 µg/ml) were studied. The antioxidant activity was studied by measuring inhibition of hydroxyl radicals generated by the fenton reaction along with pro-oxidant and iron chelating ability. PnAl showed highly significant in vitro free radical scavenging ability when compared to DMSO above 250 µg/ml concentration. PnAq showed significant pro-oxidant activity while PnAl was devoid of it at the tested concentrations. Exposure to gamma radiation (4 Gy) caused 29.10 % increase in the frequency of chromosomal aberrations. Administration of PnAl (250 mg/kg) showed highly significant decrease in chromosomal aberrations compared to radiation treated group. Radioprotective potential of alcoholic extract was found to be more effective than the aqueous extract. Qualitative phytochemical investigation of PnAq and PnAl revealed the presence of sugars, flavonoids, alkaloid, lignans, polyphenols, tannins, coumarins and saponins. Higher radioprotective effect of the alcoholic extract may be attributed to rich presence of antioxidant polyphenolic compounds.
Page(s): 704-710
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.49(09) [September 2011]

Files in This Item:

File Description SizeFormat
IJEB 49(9) 704-710.pdf175.56 kBAdobe PDFView/Open
 Current Page Visits: 595 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 585289 since 06-Feb-2009  Last updated on 17-Sep-2014Webmaster: nopr@niscair.res.in