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Title: Analgesic activity of the aqueous seed extract of Hunteria umbellata (K. Schum.) Hallier f. in rodents
Authors: Adeyemi, Olufunmilayo Olaide
Adeneye, Adejuwon Adewale
Alabi, Tope Elizabeth
Keywords: Analgesic activity;Aqueous seed extract;Hunteria umbellata;Rodents
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
Abstract: The analgesic effect and possible mechanism(s) of action of 50-200 mg/kg of the aqueous seed extract of H. umbellata (HU) were investigated in different experimental models of analgesia using the tail flick, tail immersion, acetic acid-induced writhing tests and formalin-induced algesia. Oral pre-treatment with 50-200 mg/kg of HU caused significant and dose related analgesic effect in the treated rats in all the experimental models used. This analgesia was mediated via central and peripheral mechanisms. Overall, the results showed that HU possesses analgesic effect which lends support to its folkloric use in the local management of pain.
Page(s): 698-703
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(09) [September 2011]

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