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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(09) [September 2011] >
| Title: | Effect of green tea (Camellia sinensis L.) extract on morphological and functional changes in adult male gonads of albino rats |
| Authors: | Chandra, Amar K
Choudhury, Shyamosree Roy
De, Neela
Sarkar, Mahitosh |
| Keywords: | FSH
Green tea
LH
Sperm count
Testicular ∆5-3 -HSD
Testicular 17-HSD
Testosterone |
| Issue Date: | Sep-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Green
tea, prepared from the steamed and dried leaves of the shrub Camellia sinensis, is known for its
antioxidant and anti-carcinogenic effects. However, its effects on male gonadal
functions have not been explored adequately and the present investigation has
been undertaken to evaluate the effect of green tea extract on gonads of adult
male albino rats. Results of in vivo
studies showed that green tea extract (GTE) at mild (1.25 g%, ≡ 5 cups of
tea/day), moderate (2.5 g%, ≡ 10 cups of tea/day) and high (5.0 g%, ≡ 20 cups
of tea/day) doses, for a period of 26 days, altered morphology and histology of
testis and accessory sex organs. A significant dose-dependent decrease in the
sperm counts, inhibited activities of testicular ∆53- and
17-hydroxysteroid dehydrogenase (∆5-3-HSD and 17-HSD
respectively) and decreased serum testosterone level were noticed. Significant
increase in serum LH level was observed after moderate and high doses; serum
FSH level also increased but not significantly. Histopathological examination
showed inhibition of spermatogenesis evidenced by preferential loss of matured
and elongated spermatids. Results of this study showed that GTE at relatively
high dose may cause impairment of both the morphological and normal functional
status of testis in rodents and thus its consumption at relatively high doses
raises concern on male reproductive function in spite of its other beneficial
effects. |
| Page(s): | 689-697 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(09) [September 2011]
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