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Title: Effect of oleic, lauric and myristic acids on phenylephrine-induced contractions of isolated rat vas deferens
Authors: Arruzazabala, ML
Pérez, Y
Ravelo, Y
Molina, V
Carbajal, D
Mas, R
Rodríguez, E
Keywords: D-004
lauric and myristic acids
Phenylefrine induced contractions
Vas deferens
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
Abstract: D-004, a lipid extract of Roystonea regia fruits that contains oleic, lauric and myristic acids as major components inhibits α1-adrenoreceptors-mediated contractile responses in isolated rat vas deferens and prostate trips; no study has demonstrated a similar effect for oleic, lauric or myristic acids individually. Therefore, the effects of D-004 (250 g/ml), oleic (100 g/ml), lauric (50 g/ml) or myristic (25 g/mL) acids and their combined effects on phenylephrine (PHE: 10-7- 10-4 mol/L) induced contractions has been studied. No treatment changed the basal tone of the preparations, but all inhibited PHE-induced contractions. D-004 produced the highest inhibition, followed by lauric acid, which was more effective than myristic and oleic acids against PHE-induced contractions of control group. D-004 and the mixture of the three acids produced similar inhibitions
Page(s): 684-688
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.49(09) [September 2011]

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