Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/12614
Title: Effect of oleic, lauric and myristic acids on phenylephrine-induced contractions of isolated rat vas deferens
Authors: Arruzazabala, ML
Pérez, Y
Ravelo, Y
Molina, V
Carbajal, D
Mas, R
Rodríguez, E
Keywords: D-004
Oleic
lauric and myristic acids
Phenylefrine induced contractions
Vas deferens
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
Abstract: D-004, a lipid extract of <i style="">Roystonea regia </i>fruits that contains oleic, lauric and myristic acids as major components inhibits α1-adrenoreceptors-mediated contractile responses in isolated rat vas deferens and prostate trips; no study has demonstrated a similar effect for oleic, lauric or myristic acids individually. Therefore, the effects of D-004 (250 <img src='/image/spc_char/micro.gif' border=0> g/ml), oleic (100 <img src='/image/spc_char/micro.gif' border=0> g/ml), lauric (50 <img src='/image/spc_char/micro.gif' border=0>g/ml) or myristic (25 <img src='/image/spc_char/micro.gif' border=0>g/mL) acids and their combined effects on phenylephrine (PHE: 10<sup>-7</sup>- 10<sup>-4 </sup>mol/L) induced contractions has been studied. No treatment changed the basal tone of the preparations, but all inhibited PHE-induced contractions. D-004 produced the highest inhibition, followed by lauric acid, which was more effective than myristic and oleic acids against PHE-induced contractions of control group. D-004 and the mixture of the three acids produced similar inhibitions
Description: 684-688
URI: http://hdl.handle.net/123456789/12614
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(09) [September 2011]

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