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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(09) [September 2011] >
| Title: | Effect of oleic, lauric and myristic acids on phenylephrine-induced contractions of isolated rat vas deferens |
| Authors: | Arruzazabala, ML
Pérez, Y
Ravelo, Y
Molina, V
Carbajal, D
Mas, R
Rodríguez, E |
| Keywords: | D-004
Oleic
lauric and myristic acids
Phenylefrine induced contractions
Vas deferens |
| Issue Date: | Sep-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | D-004, a lipid extract of Roystonea regia fruits that contains
oleic, lauric and myristic acids as major components inhibits
α1-adrenoreceptors-mediated contractile responses in isolated rat vas deferens
and prostate trips; no study has demonstrated a similar effect for oleic,
lauric or myristic acids individually. Therefore, the effects of D-004 (250  g/ml),
oleic (100 g/ml),
lauric (50 g/ml)
or myristic (25 g/mL) acids and their combined effects on
phenylephrine (PHE: 10-7- 10-4 mol/L) induced
contractions has been studied. No treatment changed the basal tone of the
preparations, but all inhibited PHE-induced contractions. D-004 produced the
highest inhibition, followed by lauric acid, which was more effective than
myristic and oleic acids against PHE-induced contractions of control group.
D-004 and the mixture of the three acids produced similar inhibitions |
| Page(s): | 684-688 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(09) [September 2011]
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