Please use this identifier to cite or link to this item:
|Title:||Effect of oleic, lauric and myristic acids on phenylephrine-induced contractions of isolated rat vas deferens|
lauric and myristic acids
Phenylefrine induced contractions
|Abstract:||D-004, a lipid extract of <i style="">Roystonea regia </i>fruits that contains oleic, lauric and myristic acids as major components inhibits α1-adrenoreceptors-mediated contractile responses in isolated rat vas deferens and prostate trips; no study has demonstrated a similar effect for oleic, lauric or myristic acids individually. Therefore, the effects of D-004 (250 <img src='/image/spc_char/micro.gif' border=0> g/ml), oleic (100 <img src='/image/spc_char/micro.gif' border=0> g/ml), lauric (50 <img src='/image/spc_char/micro.gif' border=0>g/ml) or myristic (25 <img src='/image/spc_char/micro.gif' border=0>g/mL) acids and their combined effects on phenylephrine (PHE: 10<sup>-7</sup>- 10<sup>-4 </sup>mol/L) induced contractions has been studied. No treatment changed the basal tone of the preparations, but all inhibited PHE-induced contractions. D-004 produced the highest inhibition, followed by lauric acid, which was more effective than myristic and oleic acids against PHE-induced contractions of control group. D-004 and the mixture of the three acids produced similar inhibitions|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.49(09) [September 2011]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.