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|Title:||Effect of oleic, lauric and myristic acids on phenylephrine-induced contractions of isolated rat vas deferens|
|Keywords:||D-004;Oleic;lauric and myristic acids;Phenylefrine induced contractions;Vas deferens|
|Abstract:||D-004, a lipid extract of Roystonea regia fruits that contains oleic, lauric and myristic acids as major components inhibits α1-adrenoreceptors-mediated contractile responses in isolated rat vas deferens and prostate trips; no study has demonstrated a similar effect for oleic, lauric or myristic acids individually. Therefore, the effects of D-004 (250 g/ml), oleic (100 g/ml), lauric (50 g/ml) or myristic (25 g/mL) acids and their combined effects on phenylephrine (PHE: 10-7- 10-4 mol/L) induced contractions has been studied. No treatment changed the basal tone of the preparations, but all inhibited PHE-induced contractions. D-004 produced the highest inhibition, followed by lauric acid, which was more effective than myristic and oleic acids against PHE-induced contractions of control group. D-004 and the mixture of the three acids produced similar inhibitions|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.49(09) [September 2011]|
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