Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/12613
Title: Effect of <i>Zataria multiflora Bois</i> L. on histamine (H<sub>1</sub>) receptor of guinea pig tracheal chains
Authors: Boskabady, Mohammad Hossein
Tabanfar, Hengameh
Keywords: Guinea pig
Histamine receptor
Inhibitory effect
Trachea
<i>Zataria multiflora Bois</i>
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
Abstract: The effects of three concentrations (2.5, 5 and 10 mg/ml) of aqueous-ethanolic extract of <i>Z. multiflora bois</i>, 10 nM chlorpheniramine, and saline on histamine (H<sub>1</sub>) receptors were tested on two groups of guinea pig tracheal chains [trachea incubated with indomethacin (Gr. 1), and indomethacin and propranolol (Gr. 2)]. The effective concentration of histamine causing 50% of maximum response (EC<sub>50</sub>) obtained in presence of chlorpheniramine in both groups, all concentrations of the extract in group 1 and its two higher concentrations in group 2 were significantly greater than those of saline. The values of concentration ratio minus one (CR-1) obtained in presence of all the three concentrations of the extract in group 1 and 10 mg/ml concentration in group 2 were significantly greater than those of chlorpheniramine. The values of EC<sub>50</sub> obtained in presence of all the three concentrations of extract and CR-1 obtained in the presence of 2.5 and 5 mg/ml concentrations in group 2 were lower than group 1. There was not significant difference in maximum response obtained in presence of different concentrations of extract between two groups. There were parallel right ward shift in concentration response curves obtained in presence of all concentrations of the extract in both the groups. These results indicated an inhibitory effect of <i>Z. multiflora</i> at histamine H<sub>1</sub> receptors.
Description: 679-683
URI: http://hdl.handle.net/123456789/12613
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(09) [September 2011]

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