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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(09) [September 2011] >
| Title: | Effect of Zataria multiflora Bois L. on histamine (H1) receptor of guinea pig tracheal chains |
| Authors: | Boskabady, Mohammad Hossein
Tabanfar, Hengameh |
| Keywords: | Guinea pig
Histamine receptor
Inhibitory effect
Trachea
Zataria multiflora Bois |
| Issue Date: | Sep-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The
effects of three concentrations (2.5, 5 and 10 mg/ml) of aqueous-ethanolic extract of Z. multiflora bois, 10 nM chlorpheniramine, and saline on histamine
(H1) receptors were tested on two groups of guinea pig tracheal
chains [trachea incubated with indomethacin (Gr. 1), and indomethacin and
propranolol (Gr. 2)]. The effective concentration of histamine causing 50% of
maximum response (EC50) obtained in presence of chlorpheniramine in
both groups, all concentrations of the extract in group 1 and its two higher
concentrations in group 2 were significantly greater than those of saline. The
values of concentration ratio minus one (CR-1) obtained in presence of all the
three concentrations of the extract in group 1 and 10 mg/ml concentration in group 2 were significantly
greater than those of chlorpheniramine. The values of EC50 obtained
in presence of all the three concentrations of extract and CR-1 obtained in the
presence of 2.5 and 5 mg/ml concentrations in group 2 were lower than group 1. There was not
significant difference in maximum response obtained in presence of different
concentrations of extract between two groups. There were parallel right ward
shift in concentration response curves obtained in presence of all
concentrations of the extract in both the groups. These results indicated an
inhibitory effect of Z. multiflora at histamine H1 receptors. |
| Page(s): | 679-683 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(09) [September 2011]
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