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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(08) [August 2011] >
| Title: | Evaluation of antioxidant and neuroprotective effect of date palm (Phoenix dactylifera L.) against bilateral common carotid artery occlusion in rats |
| Authors: | Pujari, Rohini R
Vyawahare, Neeraj S
Kagathara, Virendra G |
| Keywords: | Bilateral common cerebral artery occlusion
Flavonoids
Oxidative stress
Phoenix dactylifera |
| Issue Date: | Aug-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The
cerebral ischemia in rats was induced by occluding bilateral common carotid
arteries (BCCAO) for 30 min., followed by 45 min reperfusion. BCCAO caused
significant depletion in superoxide dismutase, catalase, glutathione,
glutathione peroxidase, glutathione-S-transferase, glutathione reductase and
significant increase in lipid peroxidation along with severe neuronal damage in
the brain. All the alterations except depletion in glutathione peroxidase and
glutathione-S-transferase levels induced by cerebral ischemia were
significantly attenuated by 15 days pretreatment with methanolic extract of P. dactylifera fruits (100, 300 mg/kg),
whereas 30 mg/kg dose was insignificant in this regard. These results suggest
the possible use P. dactylifera
against bilateral common carotid artery occlusion induced oxidative stress and
neuronal damage |
| Page(s): | 627-633 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(08) [August 2011]
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