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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(08) [August 2011] >
| Title: | Anti-depressant-like activity of a novel serotonin type-3 (5-HT3) receptor antagonist in rodent models of depression |
| Authors: | Gupta, Deepali
Devadoss, Thangaraj
Bhatt, Shvetank
Gautam, Baldev
Jindal, Ankur
Pandey, Dilip
Mahesh, Radhakrishnan |
| Keywords: | Anti-depressant-like effect
Depression
Forced swim test
5-HT3 antagonist
Quinoxalin-2-carboxamide
Serotonin |
| Issue Date: | Aug-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | N-Cyclohexyl-3-methoxyquinoxalin-2-carboxamide (QCM-13), a novel 5-HT3
antagonist identified from a series of compounds with higher pA2
(7.6) and good log P (2.91) value was screened in rodent models of depression
such as forced swim test (FST), tail suspension test (TST), interaction studies
with standard anti-depressants and confirmatory studies such as reversal of
parthenolide induced depression and reserpine induced hypothermia. In FST (2
and 4 mg/kg) and TST (2 and 4 mg/kg), QCM-13 significantly reduced the duration
of immobility in mice without affecting the base line locomotion. QCM-13 (2 and
4 mg/kg) was also found to have significant interaction with standard
anti-depressants (fluoxetine and bupropion in FST and TST respectively).
Further, reversal of parthenolide induced depression in mice and reserpine
induced hypothermia in rat models indicate the serotonergic influence of QCM-13
for anti-depressant potential. |
| Page(s): | 619-626 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(08) [August 2011]
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