|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(08) [August 2011] >
| Title: | Possible nitric oxide mechanism in the protective effect of hesperidin against ischemic reperfusion cerebral injury in rats |
| Authors: | Gaur, Vaibhav
Aggarwal, Aditi
Kumar, Anil |
| Keywords: | Bilateral common carotid artery occlusion
Hesperidin
Ischemia
Oxidative stress
Respiratory enzyme activity
Stroke |
| Issue Date: | Aug-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Stroke is the third leading cause of death
and disability around the globe. The aim of the present investigation was to
evaluate the protective effect of hesperidin and its nitric oxide mechanism
against cerebral ischemia reperfusion injury. Bilateral common carotid artery
occlusion for 30 min followed by 24 h reperfusion was given to induce ischemia
in rats. Animals were pretreated with hesperidin (50 and 100 mg/kg, po) for 7
days. Various behavioural tests, oxidative stress parameters, endogenous
antioxidant system, antioxidant enzyme activity and mitochondrial enzyme
complex (I, II, III and IV) dysfunctions in cortex and striatum were assessed
subsequently. Hesperidin (50 and
100 mg/kg) significantly improved neurobehavioral alterations (neurological
score, locomotor activity, resistance to lateral push and hanging wire
latency), attenuated oxidative damage, restored antioxidant and mitochondrial
complex enzyme activities in cortex and in striatum regions of the brain as
compared to their respective controls. L-arginine (100 mg/kg) or L-NAME (10
mg/kg) pretreatment with lower dose of hesperidin (50 mg/kg) significantly
reversed or potentiated its protective effect, respectively which was
significant as compared to hesperidin (50 mg/kg). The results highlight the
involvement of nitric oxide mechanism in the protective effect of hesperidin
against ischemia reperfusion injury induced alterations. |
| Page(s): | 609-618 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(08) [August 2011]
|
|
