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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(08) [August 2011] >
| Title: | Synthesis and anticancer activity of some new series of 1, 4-dihydropyridine derivatives |
| Authors: | Kumar, R Surendra
Idhayadhulla, A
Nasser, A Jamal Abdul
Murali, K |
| Keywords: | 1,4-Dihydropyridine
Semicarbazide
Thiosemi-carba-zide
Condensation
Anti-cancer activity |
| Issue Date: | Aug-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A series of 1,4-dihydropyridine derivatives 1a-c have been prepared from 4-substituted
aromatic aldehyde, ethyl acetoacetate and ammonium hydroxide following Hantzsch
method. The compounds 1a-c have been reacted with semicarbazide to give
the compounds 2a-c. The compounds 1a-c have been reacted with
thiosemicarbazide to give the compounds 3a-c. The structures of
synthesized compounds are confirmed by IR, ¹H and ¹³C NMR, mass spectrometry
and elemental analyses. The newly synthesized compounds have been screened for
preliminary anti-cancer activity against HepG2 (Liver), Hela (Cervical) and
MCF-7 (Breast) cancer cells. The compound 2a is highly
active against HepG2, MCF-7 and 3a is highly active against Hela
(Cervical) and these have been selected for advanced preclinical development. |
| Page(s): | 1140-1144 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(08) [August 2011]
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