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Title: Synthesis and anticancer activity of some new series of 1, 4-dihydropyridine derivatives
Authors: Kumar, R Surendra
Idhayadhulla, A
Nasser, A Jamal Abdul
Murali, K
Keywords: 1,4-Dihydropyridine;Semicarbazide;Thiosemi-carba-zide;Condensation;Anti-cancer activity
Issue Date: Aug-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of 1,4-dihydropyridine derivatives 1a-c have been prepared from 4-substituted aromatic aldehyde, ethyl acetoacetate and ammonium hydroxide following Hantzsch method. The compounds 1a-c have been reacted with semicarbazide to give the compounds 2a-c. The compounds 1a-c have been reacted with thiosemicarbazide to give the compounds 3a-c. The structures of synthesized compounds are confirmed by IR, ¹H and ¹³C NMR, mass spectrometry and elemental analyses. The newly synthesized compounds have been screened for preliminary anti-cancer activity against HepG2 (Liver), Hela (Cervical) and MCF-7 (Breast) cancer cells. The compound 2a is highly active against HepG2, MCF-7 and 3a is highly active against Hela (Cervical) and these have been selected for advanced preclinical development.
Page(s): 1140-1144
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(08) [August 2011]

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