|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(08) [August 2011] >
| Title: | Design, synthesis and pharmacological evaluation of 1,3,4-oxadizole derivatives of aryl acetic acid as anti-inflammatory and analgesic agents |
| Authors: | Amir, Mohammad
Saifullah, Khalid
Akhter, Wasim |
| Keywords: | Oxadiazole
Acetamide
Anti-inflammatory
Analgesic |
| Issue Date: | Aug-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A series of substituted 1,3,4-oxadiazole
derivatives 2a-e and 4a-e have been synthesized from diphenyl
acetic acid hydrazide under various reaction conditions. These compounds have
been tested in-vivo for their
anti-inflammatory and analgesic activities. The compound 2-[(5-diphenylmethyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(3-chloro-4-fluro-phenyl)-acetamide
4b has emerged as the
most active compound of the series, and is found to be moderately more potent
than standard drug ibuprofen. |
| Page(s): | 1107-1111 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(08) [August 2011]
|
|
