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IJC-B Vol.50B(08) [August 2011] >


Title: Design, synthesis and pharmacological evaluation of 1,3,4-oxadizole derivatives of aryl acetic acid as anti-inflammatory and analgesic agents
Authors: Amir, Mohammad
Saifullah, Khalid
Akhter, Wasim
Keywords: Oxadiazole
Acetamide
Anti-inflammatory
Analgesic
Issue Date: Aug-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of substituted 1,3,4-oxadiazole derivatives 2a-e and 4a-e have been synthesized from diphenyl acetic acid hydrazide under various reaction conditions. These compounds have been tested in-vivo for their anti-inflammatory and analgesic activities. The compound 2-[(5-diphenylmethyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(3-chloro-4-fluro-phenyl)-acetamide 4b has emerged as the most active compound of the series, and is found to be moderately more potent than standard drug ibuprofen.
Page(s): 1107-1111
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.50B(08) [August 2011]

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