Please use this identifier to cite or link to this item:
|Title:||Design, synthesis and pharmacological evaluation of 1,3,4-oxadizole derivatives of aryl acetic acid as anti-inflammatory and analgesic agents|
|Abstract:||A series of substituted 1,3,4-oxadiazole derivatives <b>2a-e</b> and <b>4a-e</b> have been synthesized from diphenyl acetic acid hydrazide under various reaction conditions. These compounds have been tested <i style="">in-vivo</i> for their anti-inflammatory and analgesic activities. The compound 2-[(5-diphenylmethyl-1,3,4-oxadiazol-2-yl)sulfanyl]-<i style="">N</i>-(3-chloro-4-fluro-phenyl)-acetamide <b>4b</b> has emerged as the most active compound of the series, and is found to be moderately more potent than standard drug ibuprofen.|
|Appears in Collections:||IJC-B Vol.50B(08) [August 2011]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.