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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(08) [August 2011] >
| Title: | Sodium borohydride / methoxydiethylborane mediated syn-1,3-stereoselective total synthesis of Herbarumin-III |
| Authors: | Yadav, J S
Narasimhulu, G
Reddy, Y Vikram
Reddy, B V Subba
Ghamdi, Ahmad Al Khazim Al |
| Keywords: | Macrolactone
Alkylation
Sharpless epoxidation
NaBH4
Et2BOMe
Stereoselective syn-1,3-reduction
Ring-closing metathesis (RCM) |
| Issue Date: | Aug-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A simple and efficient stereoselective total
synthesis of 10-membered macrolide, herbarumin-III is described. The key steps
involved in this synthesis are the selective terminal alkylation of ethyl
acetoacetate with ethyl bromide, Sharpless epoxidation, NaBH4/Et2BOMe
mediated stereoselective syn-1,3-asymmetric reduction, esterification
and olefin metathesis. |
| Page(s): | 1075-1082 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(08) [August 2011]
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