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Title: Sodium borohydride / methoxydiethylborane mediated syn-1,3-stereoselective total synthesis of Herbarumin-III
Authors: Yadav, J S
Narasimhulu, G
Reddy, Y Vikram
Reddy, B V Subba
Ghamdi, Ahmad Al Khazim Al
Keywords: Macrolactone;Alkylation;Sharpless epoxidation;NaBH4;Et2BOMe;Stereoselective syn-1,3-reduction;Ring-closing metathesis (RCM)
Issue Date: Aug-2011
Publisher: NISCAIR-CSIR, India
Abstract: A simple and efficient stereoselective total synthesis of 10-membered macrolide, herbarumin-III is described. The key steps involved in this synthesis are the selective terminal alkylation of ethyl acetoacetate with ethyl bromide, Sharpless epoxidation, NaBH4/Et2BOMe mediated stereoselective syn-1,3-asymmetric reduction, esterification and olefin metathesis.
Page(s): 1075-1082
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(08) [August 2011]

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