Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/12511
Title: Sodium borohydride<sup> </sup>/<sup> </sup>methoxydiethylborane mediated <i>syn</i>-1,3-stereoselective total synthesis of Herbarumin-III
Authors: Yadav, J S
Narasimhulu, G
Reddy, Y Vikram
Reddy, B V Subba
Ghamdi, Ahmad Al Khazim Al
Keywords: Macrolactone
Alkylation
Sharpless epoxidation
NaBH<sub>4</sub>
Et<sub>2</sub>BOMe
Stereoselective <i>syn</i>-1,3-reduction
Ring-closing metathesis (RCM)
Issue Date: Aug-2011
Publisher: NISCAIR-CSIR, India
Abstract: A simple and efficient stereoselective total synthesis of 10-membered macrolide, herbarumin-III is described. The key steps involved in this synthesis are the selective terminal alkylation of ethyl acetoacetate with ethyl bromide, Sharpless epoxidation, NaBH<sub>4</sub>/Et<sub>2</sub>BOMe mediated stereoselective <i>syn</i>-1,3-asymmetric reduction, esterification and olefin metathesis.
Description: 1075-1082
URI: http://hdl.handle.net/123456789/12511
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(08) [August 2011]

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