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Indian Journal of Chemistry -Section A (IJC-A) >
IJC-A Vol.50A [2011] >
IJC-A Vol.50A(08) [August 2011] >
| Title: | Electrochemical sensor for the simultaneous voltammetric determination of adenosine and adenine |
| Authors: | Goyal, Rajendra N
Bishnoi, Sunita
Singh, Rakesh K |
| Keywords: | Electrochemistry
Electroxidation
Nanotubes
Carbon nanotubes
Single walled carbon nanotubes
Adenine
Adenosine
Square wave voltammetry |
| Issue Date: | Aug-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Electrochemical method based on voltammetry using bare and single walled
carbon nanotubes (SWNT) modified edge plane pyrolytic graphite electrode
(EPPGE) is proposed for the simultaneous determination of adenosine and adenine
in phosphate buffer medium of pH 7.2. The oxidation peak current of both
the analytes increases significantly along with the negative shift of peak
potentials using SWNT/EPPGE as compared to bare EPPGE. The modified electrode
exhibits enhanced electrocatalytic properties towards adenosine and adenine
with a peak potential of ~ 1190 mV and ~ 856 mV, respectively. Oxidation of both the compounds occurs
in a pH-dependent process, and the
electrode reaction follows diffusion controlled pathway. The
concentration versus peak current plots are linear for both the analytes. The
detection limit (3σ/slope) observed for adenine and adenosine are 1.1 and 2.9 µM,
respectively. The developed protocol has been implemented for the simultaneous
determination of adenosine and adenine in human urine samples of normal
subjects with good results. |
| Page(s): | 1026-1034 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Source: | IJC-A Vol.50A(08) [August 2011]
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