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Title: Emerging trends in tuberculosis therapy—A review
Authors: Agrawal, Yadvendra K
Bhatt, Hardik G
Raval, Hitesh G
Oza, Pratik M
Vaidya, Hitesh B
Keywords: Antimycobacterial agents;Cell envelope;Drugs, MIC;Mycobacterium tuberculosis;Therapeutic agents;Targets
Issue Date: Mar-2007
Publisher: CSIR
Abstract: Tuberculosis is one of the most devastating bacterial disease having high rates of morbidity and mortality. Mycobacterium tuberculosis invades the host immune system and persists in pulmonary granulomas. Review presents bacterial cell wall or envelope structure, drug targets against M. tuberculosis and novel therapeutics agents like quinolone, pyrimidine, nitroimidazopyran and oxazolidinone derivatives. This review also focuses on the newer untouched targets like immunomodulators and isocitrate lyase inhibitors, which can be further exploited.
Page(s): 191-208
ISSN: 0022-4456
Appears in Collections:JSIR Vol.66(03) [March 2007]

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