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Indian Journal of Chemistry -Section A (IJC-A) >
IJC-A Vol.50A [2011] >
IJC-A Vol.50A(07) [July 2011] >
| Title: | DNA binding and cleavage activities of cationic dinuclear copper(II) and nickel(II) complexes with novel oxime-thiosemicarbazones |
| Authors: | Haribabu, P
Reddy, K Hussain |
| Keywords: | Bioinorganic chemistry
DNA cleavage
Copper
Nickel
Thiosemicarbazones
Oximes |
| Issue Date: | Jul-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Complexes of Cu(II) and Ni(II) with novel type of ligands, viz., diacetylmonoximethiosemicarbazone,
diacetylmonoxime-N(4)-methylthiosemicarbazone, diacetylmonoxime-N(4)-ethylthiosemicarbazone
and diacetylmonoxime-N(4)-phenyl- thiosemicarbazone have been
synthesized and characterized based on molar conductance, magnetic moment,
electronic, IR and ESR spectral data. Electrochemical behaviour of these
complexes is investigated by cyclic voltammetric studies. The binding
properties of these complexes with calf-thymus DNA have been investigated using
absorption spectrophotometry. Cleavage activity of these complexes has been
investigated on double stranded pBR 322 plasmid DNA by gel electrophoresis
experiments in the absence and in the presence of oxidant. |
| Page(s): | 996-1001 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Source: | IJC-A Vol.50A(07) [July 2011]
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