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Title: DNA binding and cleavage activities of cationic dinuclear copper(II) and nickel(II) complexes with novel oxime-thiosemicarbazones
Authors: Haribabu, P
Reddy, K Hussain
Keywords: Bioinorganic chemistry;DNA cleavage;Copper;Nickel;Thiosemicarbazones;Oximes
Issue Date: Jul-2011
Publisher: NISCAIR-CSIR, India
Abstract: Complexes of Cu(II) and Ni(II) with novel type of ligands, viz., diacetylmonoximethiosemicarbazone, diacetylmonoxime-N(4)-methylthiosemicarbazone, diacetylmonoxime-N(4)-ethylthiosemicarbazone and diacetylmonoxime-N(4)-phenyl- thiosemicarbazone have been synthesized and characterized based on molar conductance, magnetic moment, electronic, IR and ESR spectral data. Electrochemical behaviour of these complexes is investigated by cyclic voltammetric studies. The binding properties of these complexes with calf-thymus DNA have been investigated using absorption spectrophotometry. Cleavage activity of these complexes has been investigated on double stranded pBR 322 plasmid DNA by gel electrophoresis experiments in the absence and in the presence of oxidant.
Page(s): 996-1001
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.50A(07) [July 2011]

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