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Title: Antibacterial and cytotoxic activities of Spondias pinnata (Linn. f.) Kurz fruit extract
Authors: Muhammad, Ashif
Rahman, Md. Shafiur
Kabir, ANM Hamidul
Kabir, Shaila
Hossain, Md. Khalid
Keywords: Spondias pinnata;Anacardiaceae;Antibacterial;Cytotoxic;Fruit
Issue Date: Jun-2011
Publisher: NISCAIR-CSIR, India
IPC Code: A61K 36/00, A61P 31/04
Abstract: The plant Spondias pinnata (Linn. f.) Kurz belonging to Anacardiaceae family, is used as a medicinal agent in Bangladesh. In the present investigation, attempt was undertaken to study the antibacterial potency and cytotoxic activity of 80% ethanol extract of its fruit. The antibacterial activity was performed by the disc diffusion method and cytotoxicity was observed by brine shrimp lethality bioassay. The fruit extract exhibited mild to potent antibacterial activity against some Gram-positive and Gram-negative bacteria at a concentration of 500 µg/disc. Among them Pseudomonas aeruginosa and Staphylococcus epidermidis shows promising result. The ethanolic extract revealed strong cytotoxicity having LC50 of 2.12±0.09 µg/ml.
Page(s): 265-267
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Appears in Collections:IJNPR Vol.2(2) [June 2011]

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