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Title: Anti-microbial and wound healing activities of Cordia macleodii Hook. f & Thoms. leaves
Authors: Bhide, Bhargav
Ashok, B K
Acharya, R N
Ravishankar, B
Keywords: Anti-microbial
Cordia macleodii
Wound healing
Issue Date: Jun-2011
Publisher: NISCAIR-CSIR, India
Series/Report no.: A61K 36/30, A61K 127/00, A61P 31/00, A61P 17/02
Abstract: The present study was carried out to evaluate anti-microbial and wound healing activities of leaves of Cordia macleodii Hook. f & Thoms, a folklore medicinal plant. Anti-microbial activity was evaluated against clinically important bacteria, yeast and fungal strains using agar disc diffusion method. Excision and incision wound models were used to evaluate the wound healing activity on Wistar strain albino rats. The effects of test drug on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation, tensile strength and histopathology of the granulation tissue as well as incisional skin area. The study shows test drug is moderately sensitive against Gram positive bacteria and has no action against Gram negative bacteria. Analysis of the results generated in wound healing activity which involved studying the impact of local application of C. macleodii on excision wound, incision wound and dead space wound, show that it has no influence over excision wound contraction. It has weak tensile strength promoting property in incision wounds and neo-vascularization and ground substance formation in the dead space wounds.
Description: 198-203
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Appears in Collections:IJNPR Vol.2(2) [June 2011]

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