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Title: Evaluation of anti-inflammatory activity of Ficus carica Linn. leaves
Authors: Patil, Vikas V
Patil, Vijay R
Keywords: Leaves;Ficus carica;Moraceae;Anti-inflammatory;Indomethacin
Issue Date: Jun-2011
Publisher: NISCAIR-CSIR, India
IPC Code: A61K 36/00, A61P 29/00
Abstract: The aim of the present study was to explore the probable anti-inflammatory effect of petroleum ether (PEE), chloroform (CE) and ethanol (EE) extracts obtained from the leaves of Ficus carica Linn. Anti-inflammatory activity was studied by carrageenan-induced rat paw edema and cotton pellet granuloma methods. The extracts were administered orally in doses of 300 and 600 mg/kg/day of body weight to healthy animals. The ethanolic extract (EEFC-II) 600 mg/kg exhibited maximum anti-inflammatory effect, which is 75.90% in acute inflammation and in chronic study showed 71.66% reduction in granuloma weight. The petroleum ether (PEE), chloroform (CE) and ethanol (EE) extracts significantly reduced carrageenan-induced paw edema and cotton pellet granuloma method in rats. These extracts showed a greater anti-inflammatory effect comparative to standard drug Indomethacin.
Page(s): 151-155
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Appears in Collections:IJNPR Vol.2(2) [June 2011]

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