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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.2 [2011] >
IJNPR Vol.2(2) [June 2011] >
| Title: | Phytochemicals as radioprotective agents- A Review |
| Authors: | Paul, Piya
Unnikrishnan, M K
Nagappa, A N |
| Keywords: | Antioxidant
Cancer
Dose reduction factor
Herbals
Oxidative stress
Radiation
Radioprotectors |
| Issue Date: | Jun-2011 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | A61K 36/18, A61K 8/97, A61P 39/00, A61Q 17/00 |
| Abstract: | The development of radioprotective
agents has been a subject of intense research in view of their potential for
use within a radiation environment, such as space exploration, radiotherapy and
even nuclear war. Since no ideal, safe synthetic radioprotectors are available
to date, the search for alternative sources, including plants, has been
on-going for several decades. In the Traditional Indian system of medicine,
several plants have been used to treat radiation-mediated ailments.
A systematic screening approach can only provide leads to identify potential
new molecular entities from plant sources, for mitigation of radiation injury.
This article reviews the milestones in development of radioprotectors with
emphasis on perspectives of variety of plants, their bioactive principles and
several alternative approaches tested in in
vitro and in vivo model systems for radioprotection. With an overview
of our own work carried out in this area, this review highlights the unique
inherent properties in plants and the phytochemicals that aid in preventing
free radical-induced oxidative stress during radiation therapy. The structural
characteristics of these phytochemicals, rendering them suitable for
radioprotection, have also been discussed, with the scope of their applications
in the fields involving imbalanced redox status and oxidative stress. |
| Page(s): | 137-150 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1033 (Online); 0379-5136 (Print) |
| Source: | IJNPR Vol.2(2) [June 2011]
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