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Title: Synthesis and biological evaluation of novel oxalamido derivatives as caspase-3 inhibitors
Authors: Sengupta, Saumitra
Rao, G Venkateshwar
Dubey, P K
Keywords: Apoptosis;Caspase inhibitors;Cysteine proteases;IDN-6556;Peptidomimetic
Issue Date: Jul-2011
Publisher: NISCAIR-CSIR, India
Abstract: A new series of 5-fluoro-3-[(4-substituted-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid, 7a-c, 3-[(4-substituted-phenylaminooxalyl)-amino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid, 7d-h and 5-(2,6-difluoro-phenoxy)-3-[(substituted-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid, 7i-p have been synthesized from N-(substituted-phenyl)-oxalamic acid, 1 and their activities have been evaluated in vitro. Compounds 7b,c and k show low micromolar inhibitory activity against caspase-3.
Page(s): 901-905
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(07) [July 2011]

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