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|Title:||Synthesis and biological evaluation of novel oxalamido derivatives as caspase-3 inhibitors|
Rao, G Venkateshwar
Dubey, P K
|Keywords:||Apoptosis;Caspase inhibitors;Cysteine proteases;IDN-6556;Peptidomimetic|
|Abstract:||A new series of 5-fluoro-3-[(4-substituted-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid, 7a-c, 3-[(4-substituted-phenylaminooxalyl)-amino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid, 7d-h and 5-(2,6-difluoro-phenoxy)-3-[(substituted-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid, 7i-p have been synthesized from N-(substituted-phenyl)-oxalamic acid, 1 and their activities have been evaluated in vitro. Compounds 7b,c and k show low micromolar inhibitory activity against caspase-3.|
|Appears in Collections:||IJC-B Vol.50B(07) [July 2011]|
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