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IJC-B Vol.50B(07) [July 2011] >

Title: Synthesis and antibacterial activity of benzamides and sulfonamide derived from 2-amino-5-bromo/nitropyridine against bacterial strains isolated from clinical patients
Authors: Rai, Diwakar
Singh, Ramendra K
Keywords: Benzamides
Antibacterial activity
Microdilution broth susceptibility test
Issue Date: Jul-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of 5-(bromo/nitropyridin-2-yl)benzamide derivatives, viz. N-(5-bromopyridin-2-yl)benzamide 4a, 4-methyl-N-(5-bromopyridin-2-yl)benzamide 4b, 4-chloro-N-(5-bromopyridin-2-yl)benzamide 4c, 4-nitro-N-(5-bromopyridin-2-yl)benzamide 4d, N-(5-nitropyridin-2-yl)benzamide 7a, 4-methyl-N-(5-nitropyridin-2-yl)benzamide 7b, 4-chloro-N-(5-nitropyridin-2-yl)benzamide 7c, 4-nitro-N-(5-nitropyridin-2-yl)benzamide 7c and a sulfo­namide derivative, N-benzoyl-N-(5-bromopyridin-2-yl)trifluoro­methane sulfonamide 5 have been synthesized  as novel  anti­bacterial agents. All compounds have shown promising activity (MIC 0.22–1.49 M) against Gram-positive and Gram-negative bacterial strains using microdilution broth susceptibility test method. The sulfonamide 5 showed much better results than other compounds and its MIC values predicted it to be a lead compound as an antibacterial agent.
Page(s): 931-936
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.50B(07) [July 2011]

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