Please use this identifier to cite or link to this item:
Title: Synthesis and antibacterial activity of benzamides and sulfonamide derived from 2-amino-5-bromo/nitropyridine against bacterial strains isolated from clinical patients
Authors: Rai, Diwakar
Singh, Ramendra K
Keywords: Benzamides
Antibacterial activity
Microdilution broth susceptibility test
Issue Date: Jul-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of 5-(bromo/nitropyridin-2-yl)benzamide derivatives, <i style="">viz.</i> <i>N</i>-(5-bromopyridin-2-yl)benzamide<b> 4a</b><b style="">,</b> 4-methyl-<i>N</i>-(5-bromopyridin-2-yl)benzamide <b>4b, </b>4-chloro-<i>N</i>-(5-bromopyridin-2-yl)benzamide<b> 4c, </b>4-nitro-<i>N</i>-(5-bromopyridin-2-yl)benzamide<b> 4d</b>, <i>N</i>-(5-nitropyridin-2-yl)benzamide<b> 7a</b><b style="">,</b> 4-methyl-<i>N</i>-(5-nitropyridin-2-yl)benzamide<b> 7b</b><b style="">,</b> 4-chloro-<i>N</i>-(5-nitropyridin-2-yl)benzamide <b>7c</b><b style="">,</b> 4-nitro-<i>N</i>-(5-nitropyridin-2-yl)benzamide<b> 7c </b>and a sulfo­namide derivative, <i>N</i>-benzoyl-<i>N</i>-(5-bromopyridin-2-yl)trifluoro­methane sulfonamide<b> 5 </b>have been synthesized&nbsp; as novel&nbsp; anti­bacterial agents. All compounds have shown promising activity (MIC 0.22–1.49 <img src='/image/spc_char/micro.gif' border=0>M) against Gram-positive and Gram-negative bacterial strains using microdilution broth susceptibility test method. The sulfonamide <b style="">5</b> showed much better results than other compounds and its MIC values predicted it to be a lead compound as an antibacterial agent.
Description: 931-936
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(07) [July 2011]

Files in This Item:
File Description SizeFormat 
IJCB 50B(7) 931-936.pdf83.85 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.