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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(07) [July 2011] >
| Title: | Synthesis and antibacterial activity of benzamides and sulfonamide derived from 2-amino-5-bromo/nitropyridine against bacterial strains isolated from clinical patients |
| Authors: | Rai, Diwakar
Singh, Ramendra K |
| Keywords: | Benzamides
Sulfonamides
Antibacterial activity
Microdilution broth susceptibility test
MIC/MBC |
| Issue Date: | Jul-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A series of
5-(bromo/nitropyridin-2-yl)benzamide derivatives, viz. N-(5-bromopyridin-2-yl)benzamide 4a, 4-methyl-N-(5-bromopyridin-2-yl)benzamide
4b, 4-chloro-N-(5-bromopyridin-2-yl)benzamide 4c, 4-nitro-N-(5-bromopyridin-2-yl)benzamide
4d, N-(5-nitropyridin-2-yl)benzamide 7a, 4-methyl-N-(5-nitropyridin-2-yl)benzamide 7b, 4-chloro-N-(5-nitropyridin-2-yl)benzamide
7c, 4-nitro-N-(5-nitropyridin-2-yl)benzamide
7c and a sulfonamide derivative, N-benzoyl-N-(5-bromopyridin-2-yl)trifluoromethane
sulfonamide 5 have been synthesized
as novel antibacterial agents.
All compounds have shown promising
activity (MIC 0.22–1.49  M) against Gram-positive and Gram-negative bacterial strains using microdilution broth susceptibility test method. The sulfonamide 5 showed much better results than other compounds and its MIC
values predicted it to be a lead compound as an antibacterial agent. |
| Page(s): | 931-936 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(07) [July 2011]
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