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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(07) [July 2011] >
| Title: | Synthesis and antibacterial evaluation of novel heterocycles from 5-chloro-3-methyl-1-phenylpyrazole-4-carbaldehyde |
| Authors: | Siddiqui, Zeba N
Praveen, Shagufta
Musthafa, Mohammed T N |
| Keywords: | 3-Acetyl-4-hydroxycoumarin
Dehydroacetic acid
5-chloro-3-methyl-1-phenylpyrazole-4-carbaldehyde
Pyrazolines
 -bromo- -methoxyheteroaryl ketones
Antibacterial activity |
| Issue Date: | Jul-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 5-Chloro-3-methyl-1-phenylpyrazole-4-carbaldehyde
1 reacts with acetylpyrone 2 and acetylbenzopyrone 3 via
Claisen-Schmidt condensation to afford heterochalcones 4a,b which undergo facile cyclisation with hydrazines to give
3,5-heteroaryl-2-pyrazolines 5a-d in
quantitative yield. Further, heterochalcones 4a,b undergo addition reaction using Br2/MeOH in the
presence of Pb(NO3)2 or AgNO3 to afford
addition products 6a,b. The
structures of the newly synthesized compounds have been established on the
basis of their spectral studies. The newly synthesized heterochalcones and
pyrazolines have been screened for their antibacterial activity against two
kinds of strains using the Agar well diffusion method. Some of the compounds
showed significant activity against both the strains. |
| Page(s): | 910-917 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(07) [July 2011]
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