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|Title:||Synthesis and antibacterial evaluation of novel heterocycles from 5-chloro-3-methyl-1-phenylpyrazole-4-carbaldehyde|
|Authors:||Siddiqui, Zeba N|
Musthafa, Mohammed T N
<img src='/image/spc_char/alpha.gif' border=0>-bromo-<img src='/image/spc_char/beta.gif' border=0>-methoxyheteroaryl ketones
|Abstract:||5-Chloro-3-methyl-1-phenylpyrazole-4-carbaldehyde <b style="">1</b> reacts with acetylpyrone <b style="">2 </b>and acetylbenzopyrone <b style="">3</b> <i style="">via</i> Claisen-Schmidt condensation to afford heterochalcones <b style="">4a,b</b> which undergo facile cyclisation with hydrazines to give 3,5-heteroaryl-2-pyrazolines <b style="">5a-d</b> in quantitative yield. Further, heterochalcones <b style="">4a,b</b> undergo addition reaction using Br<sub>2</sub>/MeOH in the presence of Pb(NO<sub>3</sub>)<sub>2</sub> or AgNO<sub>3</sub> to afford addition products <b style="">6a,b</b>. The structures of the newly synthesized compounds have been established on the basis of their spectral studies. The newly synthesized heterochalcones and pyrazolines have been screened for their antibacterial activity against two kinds of strains using the Agar well diffusion method. Some of the compounds showed significant activity against both the strains.|
|Appears in Collections:||IJC-B Vol.50B(07) [July 2011]|
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