|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(07) [July 2011] >
| Title: | Synthesis and antimicrobial activities of nitro substituted indolo[3,2-c]acridines |
| Authors: | Prabakaran, K
Yamuna, E
Prasad, K J Rajendra |
| Keywords: | 9-Nitro-7-phenyl-5
6-dihydro-indolo[3,2-c]acridines
9-nitro-7-phenyl-indolo[3,2-c]acridines
Anti-bacterial
Anti-fungal activities |
| Issue Date: | Jul-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The efficient synthesis of biologically
active 9-nitro-7-phenyl-5,6-dihydro-indolo[3,2-c]acridines 2a-e is
described from the reaction of
2,3,4,9-tetrahydro-1H-carbazol-1-one
with 2-amino-5-nitro-benzophenone in acetic acid and a few drops of H2SO4
at refluxing temperature. The obtained compound
1-methyl-9-nitro-7-phenyl-5,6-dihydro-indolo[3,2-c]acridine 2a on further
treatment with Pd/C in diphenyl ether affords
1-methyl-9-nitro-7-phenyl-indolo[3,2-c]acridine
3a. All the synthesized compounds
have been characterized by IR, NMR and mass spectroscopy. The anti-microbial properties of the
synthesized nitro substituted indolo[3,2-c]acridines
have been investigated. |
| Page(s): | 906-909 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(07) [July 2011]
|
|
