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IJC-B Vol.50B(07) [July 2011] >


Title: Synthesis and antimicrobial activities of nitro substituted indolo[3,2-c]acridines
Authors: Prabakaran, K
Yamuna, E
Prasad, K J Rajendra
Keywords: 9-Nitro-7-phenyl-5
6-dihydro-indolo[3,2-c]acridines
9-nitro-7-phenyl-indolo[3,2-c]acridines
Anti-bacterial
Anti-fungal activities
Issue Date: Jul-2011
Publisher: NISCAIR-CSIR, India
Abstract: The efficient synthesis of biologically active 9-nitro-7-phenyl-5,6-dihydro-indolo[3,2-c]acridines 2a-e is described from the  reaction of 2,3,4,9-tetrahydro-1H-carbazol-1-one with 2-amino-5-nitro-benzophenone in acetic acid and a few drops of H2SO4 at refluxing temperature. The obtained compound 1-methyl-9-nitro-7-phenyl-5,6-dihydro-indolo[3,2-c]acridine 2a on further treatment with Pd/C in diphenyl ether affords 1-methyl-9-nitro-7-phenyl-indolo[3,2-c]acridine 3a. All the synthesized compounds have been characterized by IR, NMR and mass spectroscopy.  The anti-microbial properties of the synthesized nitro substituted indolo[3,2-c]acridines have been investigated.
Page(s): 906-909
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.50B(07) [July 2011]

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