Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/12055
Title: Inhibition of <i style="">Naja nigricolis </i>(Reinhardt) venom protease activity by<i style=""> Luffa egyptiaca </i>(Mill) and <i style="">Nicotiana rustica </i>(Linn) extracts
Authors: Ibrahim, M A
Aliyu, A B
Abusufiyanu, A
Bashir, M
Sallau, A B
Keywords: <i style="">Luffa egyptiaca</i>
<i style="">Naja nigricolis</i>
<i style="">Nicotiana rustica</i>
Protease
Venom
Issue Date: Jul-2011
Publisher: NISCAIR-CSIR, India
Abstract: <i style="">Luffa egyptiaca </i>and <i style="">Nicotiana rustica </i>are used in traditional medicine to treat snakebites and were evaluated for inhibitory activities on <i style="">Naja nigricolis </i>venom protease. The aqueous and ethanolic extracts of <i style="">L. egyptiaca</i> significantly reduced the maximum velocity (V<sub>max</sub>) and the computed index of physiological efficiency (<i style="">K<sub>cat</sub></i>) of the enzyme in a dose dependent fashion. The protease activity was non-competitively inhibited by the aqueous extract of <i style="">N. rustica</i> with the V<sub>max</sub> significantly decreased and the K<sub>M</sub> remained unchanged. However, the<i style=""> N. rustica </i>ethanol extract completely inhibited the protease activity. Ethyl acetate fractions partitioned from ethanol extracts of both plants were also found to completely inhibit the <i style="">N. nigricolis </i>venom protease<i style=""> </i>activity at 0.1 and 0.05%. The use of these plants could be important in the treatment of snakebites.
Description: 552-554
URI: http://hdl.handle.net/123456789/12055
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(07) [July 2011]

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