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IJEB Vol.49(07) [July 2011] >


Title: Distinct synergistic action of piperacillin and methylglyoxal against Pseudomonas aeruginosa
Authors: Mukherjee, Sayanti
Chaki, Shaswati
Das, Sukhen
Sen, Saswati
Dutta, Samir Kr.
Dastidar, Sujata G.
Keywords: Antimicrobial action
Methylglyoxal
Piperacillin
Pseudomonas aeruginosa
Pseudomonas aeruginosa
Issue Date: Jul-2011
Publisher: NISCAIR-CSIR, India
Abstract: The dicarbonyl compound methylglyoxal is a natural constituent of Manuka honey produced from Manuka flowers in New Zealand. It is known to possess both anticancer and antibacterial activity. Such observations prompted to investigate the ability of methylglyoxal as a potent drug against multidrug resistant Pseudomonas aeruginosa. A total of 12 test P. aeruginosa strains isolated from various hospitals were tested for their resistances against many antibiotics, most of which are applied in the treatment of P. aeruginosa infections. Results revealed that the strains were resistant to many drugs at high levels, only piperacillin, carbenicillin, amikacin and ciprofloxacin showed resistances at comparatively lower levels. Following multiple experimentations it was observed that methylglyoxal was also antimicrobic against all the strains at comparable levels. Distinct and statistically significant synergism was observed between methylglyoxal and piperacillin by disc diffusion tests when compared with their individual effects. The fractional inhibitory concentration index of this combination evaluated by checkerboard analysis, was 0.5, which confirmed synergism between the pair. Synergism was also noted when methylglyoxal was combined with carbenicillin and amikacin.
Page(s): 547-551
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.49(07) [July 2011]

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