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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(07) [July 2011] >
| Title: | Distinct synergistic action of piperacillin and methylglyoxal against Pseudomonas aeruginosa |
| Authors: | Mukherjee, Sayanti
Chaki, Shaswati
Das, Sukhen
Sen, Saswati
Dutta, Samir Kr.
Dastidar, Sujata G. |
| Keywords: | Antimicrobial action
Methylglyoxal
Piperacillin
Pseudomonas aeruginosa
Pseudomonas aeruginosa |
| Issue Date: | Jul-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The dicarbonyl compound methylglyoxal is a natural constituent of
Manuka honey produced from Manuka flowers in New Zealand. It is known to possess
both anticancer and antibacterial activity. Such observations prompted to
investigate the ability of methylglyoxal as a potent drug against multidrug
resistant Pseudomonas aeruginosa. A
total of 12 test
P. aeruginosa strains isolated from
various hospitals were tested for their resistances against many antibiotics,
most of which are applied in the treatment of P. aeruginosa infections. Results revealed that the strains were
resistant to many drugs at high levels, only piperacillin, carbenicillin,
amikacin and ciprofloxacin showed resistances at comparatively lower levels.
Following multiple experimentations it was observed that methylglyoxal was also
antimicrobic against all the strains at comparable levels. Distinct and
statistically significant synergism was observed between methylglyoxal and
piperacillin by disc diffusion tests when compared with their individual
effects. The fractional inhibitory concentration index of this combination
evaluated by checkerboard analysis, was 0.5, which confirmed synergism between
the pair. Synergism was also noted when methylglyoxal was combined with
carbenicillin and amikacin. |
| Page(s): | 547-551 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(07) [July 2011]
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